JOÃO AUGUSTO MOURA

JOÃO AUGUSTO MOURA

(Fonte: Lattes)

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Possui graduação em Tecnologia em saúde pela Faculdade de Tecnologia de Sorocaba (2005). Mestrado em Tecnologia Nuclear pela Universidade de São Paulo (2009). Doutorado em Tecnologia Nuclear pela Universidade de São Paulo (2015). Tem experiência na área de Tecnologia Nuclear, com ênfase em produção de fontes para radioterapia. Atualmente trabalha em pesquisa e desenvolvimento no Instituto de Pesquisas Energéticas e Nucleares (IPEN/CNEN-SP). (Texto extraído do Currículo Lattes em 8 maio 2023)

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Development and production of radioactive sources for cancer tratment in Brazil
2008 - ROSTELATO, MARIA E.C.M.; RELA, PAULO R.; ZEITUNI, CARLOS A.; FEHER, ANSELMO; MANZOLI, JOSE E.; MOURA, JOAO A.; MOURA, EDUARDO S.; SILVA, CONSTANCIA P.G.
Every year, the number of cancer patients increases in Brazil and some of these patients are treated with Brachytherapy using Iridium -192 wire sources and Iodine-125 seeds. Brachytherapy is a kind of lesion treatment based on the sources insertion in the tumor. These sources can be activated iridium wires or iodine seeds. During this process, the ionizing radiation destroys the malignant cells very efficiently. The Energy and Nuclear Research Institute – IPEN, which belongs to the Nuclear Energy National Commission – CNEN, established a program for the development of the technique and production of Iridium -192 wire sources and Iodine-125 seeds in Brazil. The purpose of this program is to develop the technique and to establish a laboratory for the production of Iridium – 192 sources and Iodine-125 seeds. This project target is to enable the country with the production of these sources, making the products accessible to clinics and hospitals, with low costs for the Brazilian people reality. With the purpose of settling a laboratory for Iridium –192 sources production, a wire activation method was developed and a hot cell for the wire manipulation, quality assurance and packaging was built. The wire activation was carried out in our nuclear reactor, IEAR1m. These sources are usually shaped as flexible wires 0.3mm diameter and 50.0cm long. The specific activity, for a low dose rate (LDR) therapy, is between 1mCi/cm and 4mCi/cm. The Iodine-125 seeds consist of a titanium capsule of 0.8 mm external diameter, 0.05mm wall thickness and 4.5mm long. The inner capsule houses a silver thread, 3.0mm long and 0.5mm diameter, containing the adsorbed 125-Iodine. The typical seed apparent activity is of 0.4mCi (14.8MBq), with a recommended variation of about 5% at most, in a same lot of seeds. During the project execution, the following methods were developed: the seed core (silver) cutting, the titanium tube cutting, the iodine immobilization through its deposition in silver substrate and the sealing of the seeds through welding process, so that the classification of the seeds, as sealed sources, and the leakage tests could be done according to the international norms.
Procedimento para determinacao da descontaminacao de tubulacoes, na producao de sementes de iodo-125
2009 - MOURA, J.A.; MOURA, E.S.; SPRENGER, F.E.; NAGATOMI, H.R.; ZEITUNI, C.A.; FEHER, A.; MANZOLI, J.E.; SOUZA, C.D.; ROSTELATO, M.E.C.M.
Quality assurance procedure development in iodine-125 seeds production
2008 - MOURA, J.A.; MOURA, E.S.; SPRENGER, F.E.; NAGATOMI, H.R.; ZEITUNI, C.A.; FEHER, A.; MANZOLI, J.E.; ROSTELATO, M.E.C.M.
Quality assurance procedure development in iodine-125 seeds production
2009 - MOURA, J.A.; MOURA, E.S.; SPRENGER, F.E.; NAGATOMI, H.R.; ZEITUNI, C.A.; FEHER, A.; MANZOLI, J.E.; ROSTELATO, M.E.C.M.
Brachytherapy using Iodine-125 seeds has been used in prostate cancer treatment. In the quality control routine during seed production, leak tests are made to detect any leakage of radioactive material from inside the titanium shield. Leak tests are made according to the International Standard Organization- Radiation protection – sealed radioactive sources - ISO 9978 standard, and require liquid transfer between recipients. If any leakage happens, there will be contamination of the liquid and tubing. This study aims to establish decontamination routines for tubing, allowing its repeated use, in the automated assay process.
Tubing decontamination during the leak test of iodine-125 seeds
2010 - MOURA, JOAO A.; MOURA, EDUARDO S.; SPRENGER, FRANCISCO E.; NAGATOMI, HELIO R.; ZEITUNI, CARLOS A.; FEHER, ANSELMO; MANZOLI, JOSE E.; SOUZA, CARLA D.; ROSTELATO, MARIA E.C.M.
Leak tests were made to detect any leakage of radioactive material from inside the iodine-125 seeds applied in brachytherapy. These seeds are used in prostate cancer treatment. In the quality control routine, during seed production, leak tests are performed according to the International Standard Organization – radiation protection – sealed radioactive sources – ISO-9978 standard, and require liquid transfer between recipients. Any leakage causes contamination of the liquid and tubes. The aim of this study is the establishment of decontamination routines for tubes, allowing their repeated use, in the automated assay process.
Leakage test methodology development in iodine-125 seeds production
2013 - MOURA, JOAO A.; SOUZA, CARLA D. de; ROSTELATO, MARIA E.C.M.; MOURA, EDUARDO S. de; SPRENGER, FRANCISCO E.; NAGATOMI, HELIO R.; ZEITUNI, CARLOS A.; FEHER, ANSELMO; MANZOLI, JOSE E.
Brachytherapy using iodine-125 seeds has been used in prostate cancer treatment. In the quality control routine during seed production, leakage tests are taken to detect any leakage of radioactive material from inside the titanium shield, avoiding patient contamination. Leakage tests are carried out according to the International Standard Organization e Radiation protection e sealed radioactive sources e ISO 9978. This standard recommends different methods of essay applied to radioactive seeds. The aims of this work were the study of the different leakage test methods applied to radioactive seeds recommended by the ISO 9978 and the choice of the appropriate method to be used in the seeds production. The authors evaluated five different immersion methods to detect leakage, following the standard guidance, and in some case exceeding its requirement. One hundred iodine-125 seeds were intentionally cuted, causing the release of its content. Each immersion method was applied to twenty seeds. After the immersion period, the resulting liquid activity was measured. The activity values measured in the immersion liquid indicated best results with distilled water as immersion liquid and with the application of ultrasound to the bath. The temperature of the bath ranged from 20 C to 70 C and the immersion time ranged from 30 min to 24 h. In this experiment, the use of scintillator liquid as immersion liquid was not effective to detect the leakage. The results allow the authors to choose the best methods to be applied in the production routine, to detect leakage in the seeds. The choice of the method will also depend on the production rhythm for schedule. In a moderate production rate, the test at 20 C and 24 h immersion may be used. In a fast production rhythm, the shortest test 50 C or 70 C should be used.