The aim of this study was the preparation of a liquid kit for radiolabeling of 188Re-HEDP (hydroxyethylidene
diphosphonate).
188Re was obtained from alumina based 188W/
188Re generators. This paper reports the efficacy of a
cold kit stored for more than two weeks, determined by the dependence of the radiolabeling yields of 188Re-HEDP on
the incubation time, reducing agent concentration, the effects of concentration of ligand, the pH of the reaction and
the temperature. The cold kits showed a good stability when carrie-free rhenium-188 was added in the reaction
mixture.