SABINE NEUSATZ GUILHEN

SABINE NEUSATZ GUILHEN

(Fonte: Lattes)

Resumo

Possui graduação em Química com atribuições Tecnológicas e Biotecnológicas pelo Instituto de Química da Universidade de São Paulo (2005), mestrado (2009) e doutorado (2018) em Tecnologia Nuclear (Materiais) pelo Instituto de Pesquisas Energéticas e Nucleares (IPEN), Universidade de São Paulo. Tem experiência em Química Analítica com ênfase em Análise de Traços, atuando principalmente no desenvolvimento de métodos analíticos empregando técnicas espectrofotométricas (AAS, ICP OES e ICP-MS) para caracterização de amostras ambientais, arqueológicas, biológicas, forenses e nucleares. Atualmente, ocupa o cargo de Tecnologista em "Caracterização Química" no Centro de Química e Meio Ambiente (CQMA) do IPEN (CNEN/SP), onde desempenha atividades de pesquisa e desenvolvimento tecnológico em atendimento às demandas institucionais ligadas ao Ciclo do Combustível Nuclear e aos Programas de Pesquisa de caráter multidisciplinar, em apoio a projetos de Inovação Tecnológica e ao Programa de Pós-Graduação do IPEN/USP. Além disso, atua na geração de produtos tecnológicos e no desenvolvimento de materiais adsorventes de baixo custo e alto valor agregado visando o aproveitamento de materiais e resíduos naturais e/ou renováveis no tratamento de efluentes e rejeitos. (Texto extraído do Currículo Lattes em 4 maio 2023)

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Mercury exposure among dental staff in the Legal Amazon
2019 - VILLIBOR, FERNANDA F.; GUILHEN, SABINE N.; DANTAS, ELIZABETH S.K.; PIRES, MARIA A.F.
Elemental mercury is highly toxic and may be absorbed by dental professionals through direct skin contact or inhalation. The use of mercury in dental amalgam has been a concern of the academic community for years, for its incorporation is likely to affect vital organ systems. Several studies have been conducted to address the possible risks of occupational exposure to mercury vapor in dental offices. The present study aimed to present evidences that mercury is assimilated by exposed workers through the determination of urinary mercury (HgU) from dental professionals (n = 91) of public offices in Araguaína (Tocantins, Brazil). This uptake was verified against samples from unexposed individuals (n = 43), which activities are not dentistry related. Cold vapor atomic absorption spectrometry (CV-AAS) technique enabled the subjects’ biological monitoring. Approximately 44.8% (n = 60) of the 134 participants were aged between 21 and 30 years and were at the beginning of their professional lives; 9.7% (13) of the study participants were men and 90.3% (121) were women. Hg concentrations in all samples analyzed were within the maximum biological limit set by the World Health Organization (WHO) (<50 μgHg·L−1). HgU concentrations in dental professionals were within the limits proposed by the Brazilian regulatory standard, Regulatory Norm-7 (RN-7) (≤35 μgHg·g−1 creatinine). Nevertheless, the average concentration of HgU was approximately 8 times higher in the potentially exposed group (5.61 μgHg·g−1 creatinine) than in the unexposed group (0.65 μgHg·g−1 creatinine), highlighting the potential risk of occupational exposure to mercury.
Application of the fundamental parameter method to the assessment of major and trace elements in soil and sediments from Osamu Utsumi uranium mine by WDXRF
2019 - GUILHEN, SABINE N.; COTRIM, MARYCEL E.B.; SAKATA, SOLANGE K.; SCAPIN, MARCOS A.
Wavelength dispersive X-ray fluorescence spectrometry (WDXRF) is a suitable technique for the characterization of contaminated mining sites, providing a quick and reliable screening for areas of significant contamination. This study established and validated a non-destructive methodology for quantitative simultaneous determination of major and minor constituents in soil and sediments by WDXRF, which was further applied to quantify soil and sediment samples from Osamu Utsumi uranium mine (Caldas, Minas Gerais, Brazil). Elements such as Ce, La, Nd, Mn and U were found in more concentrated levels in the calcium diuranate deposit (DUCA), whereas Fe and Al were found at higher levels in the soil samples corresponding to sites where accentuated leaching processes have occurred. Comparatively, the levels of U and rare-earth elements were found in significantly higher levels in the sediments retrieved from the mine’s pit as a result of acid mine drainage. These findings are believed to be useful as an initial environmental assessment for the decommissioning process of the mine.
Mercury exposure among dental staff in the legal Amazon
2019 - VILLIBOR, FERNANDA F.; GUILHEN, SABINE N.; DANTAS, ELIZABETH S.K.; PIRES, MARIA A.F.
Elemental mercury is highly toxic and may be absorbed by dental professionals through direct skin contact or inhalation. The use of mercury in dental amalgam has been a concern of the academic community for years, for its incorporation is likely to affect vital organ systems. Several studies have been conducted to address the possible risks of occupational exposure to mercury vapor in dental offices. The present study aimed to present evidences that mercury is assimilated by exposed workers through the determination of urinary mercury (HgU) from dental professionals (n = 91) of public offices in Araguaína (Tocantins, Brazil). This uptake was verified against samples from unexposed individuals (n = 43), which activities are not dentistry related. Cold vapor atomic absorption spectrometry (CV-AAS) technique enabled the subjects’ biological monitoring. Approximately 44.8% (n = 60) of the 134 participants were aged between 21 and 30 years and were at the beginning of their professional lives; 9.7% (13) of the study participants were men and 90.3% (121) were women. Hg concentrations in all samples analyzed were within the maximum biological limit set by the World Health Organization (WHO) (<50 μgHg·L−1). HgU concentrations in dental professionals were within the limits proposed by the Brazilian regulatory standard, Regulatory Norm-7 (RN-7) (≤35 μgHg·g−1 creatinine). Nevertheless, the average concentration of HgU was approximately 8 times higher in the potentially exposed group (5.61 μgHg·g−1 creatinine) than in the unexposed group (0.65 μgHg·g−1 creatinine), highlighting the potential risk of occupational exposure to mercury.
Method development and validation for simultaneous determination of IEA-R1 reactor’s pool water uranium and silicon content by ICP OES
2018 - ULRICH, J.C.; GUILHEN, S.N.; COTRIM, M.E.B.; PIRES, M.A.F.
IPEN’s research reactor, IEA-R1, an open pool type research reactor moderated and cooled by light water. High quality water is a key factor in preventing the corrosion of the spent fuel stored in the pool. Leaching of radionuclides from the corroded fuel cladding may be prevented by an efficient water treatment and purification system. However, as a safety management policy, IPEN has adopted a water chemistry control which periodically monitors the levels of uranium (U) and silicon (Si) in the pool’s reactor, since IEA-R1 employs U3Si2-Al dispersion fuel. An analytical method was developed and validated for the determination of uranium and silicon by ICP OES. This work describes the validation process, in a context of quality assurance, including the parameters selectivity, linearity, quantification limit, precision and recovery.
Method development and validation for simultaneous determination of IEAR1 reactor's pool water U and Si content by ICP OES
2017 - ULRICH, JOAO C.; GUILHEN, SABINE N.; COTRIM, MARYCEL E.B.; PIRES, MARIA A.F.
Validação de metodologia analítica para determinação de mercúrio total em amostras de urina por espectrometria de absorção atômica com geração de vapor frio (CV-AAS)
2010 - GUILHEN, SABINE N.; PIRES, MARIA A.F.; DANTAS, ELIZABETH S.K.; XAVIER, FERNANDA V.
Mercury is a toxic metal used in a variety of substances over the course history. One of its more dubious uses is in dental amalgam restorations. It is possible to measure very small concentrations of this metal in the urine of exposed subjects by the cold vapor atomic absorption technique. The present work features the validation as an essential tool to confirm the suitability of the analytical method chosen to accomplish such determination. An initial analysis will be carried out in order to evaluate the environmental and occupational levels of exposure to mercury in 39 members of the auxiliary dental staff at public consulting rooms in the city of Araguaína (TO).