JORGE GABRIEL DOS SANTOS BATISTA
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Capítulo IPEN-doc 28700 The role of probiotics in maintaining immune homeostasis2022 - THIPE, VELAPHI C.; MENTOR, SHIREEN; LIMA, CAROLINE S.A.; FREITAS, LUCAS F.; FONSECA, ANA C.M.; NOGUEIRA, KAMILA M.; RODRIGUES, ADRIANA S.; BATISTA, JORGE G.S.; FERREIRA, ARYEL H.; LUGAO, ADEMAR B.The immune system is a complex architecture of a collective and coordinated network regulated by various pathways to thermodynamically maintain immune homeostasis. The gut microbiota plays a pivotal role that offers significant stimuli (i.e., gut-brain, gut-lung, and gut-liver axis) for both innate and adaptive immunity, mediating immune and metabolic homeostasis. An intricate correlation between changes in the gut microbiota (dysbiosis) and common diseases/disorders have been attributed to the invasion of pathogens, constant use of antibiotics, and hypercytokinemia—a hallmark of immune homeostasis imbalance. These factors contribute to the severity of inflammatory diseases such as cardiovascular diseases, neurological disorders, and of late the coronavirus disease, Covid-19. Probiotics (Lactobacillus spp. and Bifidobacterium spp.) have been considered as alternative and/or adjuvant therapeutic in restoring the balance of gut microbiota for maintaining immune homeostasis and integrity. The probiotics catalyze dietary fibers and proteins to generate short-chain fatty acids and tryptophan to promote antiinflammatory cytokines, reduce epithelium permeability, reinforcing immunity in the gut mucosa, and regulating the systemic immune response. Herein, we review our overarching understanding of current applications of probiotics in amelioration of gut microbiome, and the improvement of gut barrier function and maintaining immune homeostasis. We also highlight clinical trials on probiotics with reported results for the treatment of inflammatory diseases. Additionally, the looming global Covid-19 pandemic makes it prudent to highlight the role of probiotics in both the innate and adaptive human immune responses, especially amid the Covid-19 vaccination paradigm.Capítulo IPEN-doc 28699 Cu and Cu-based nanomaterials as nanofungicides2022 - THIPE, VELAPHI C.; FREITAS, LUCAS F.; LIMA, CAROLINE S.A. de; NOGUEIRA, KAMILA M.; BATISTA, JORGE G.S.; FERREIRA, ARYEL H.; LUGAO, ADEMAR B.Green nanotechnology through the production of copper and copper oxide nanoparticles (CuNPs and CuONPs, respectively) as nanofungicides brings forth the opportunity attributed to their antimicrobial properties in addition to Cu being an essential metal micronutrient that functions as a cofactor for many enzymatic activities in plants. Herein, we explore the use of CuNPs and CuONPs as nanofungicides against toxigenic fungi and their mechanism of action. We also highlight the green nanoagriculture and the ecotoxicology and safety of CuNPs and CuONPs as nanofungicides to significantly aid as agricultural breakthroughs because such approaches will provide realistic sustainable nano Cu-enabled products deemed safe for agricultural practices.Capítulo IPEN-doc 28536 Silver nanoparticles applications and ecotoxicology for controlling mycotoxins2021 - THIPE, VELAPHI C.; LIMA, CAROLINE S.A.; NOGUEIRA, KAMILA M.; BATISTA, JORGE G.S.; FERREIRA, ARYEL H.; KATTI, KATTESH V.; LUGAO, ADEMAR B.Artigo IPEN-doc 28073 The state of the art of theranostic nanomaterials for lung, breast, and prostate cancers2021 - FREITAS, LUCAS F.; FERREIRA, ARYEL H.; THIPE, VELAPHI C.; VARCA, GUSTAVO H.C.; LIMA, CAROLINE S.A.; BATISTA, JORGE G.S.; RIELLO, FABIANE N.; NOGUEIRA, KAMILA; CRUZ, CASSIA P.C.; MENDES, GIOVANNA O.A.; RODRIGUES, ADRIANA S.; SOUSA, THAYNA S.; ALVES, VICTORIA M.; LUGAO, ADEMAR B.The synthesis and engineering of nanomaterials offer more robust systems for the treatment of cancer, with technologies that combine therapy with imaging diagnostic tools in the so‐called nanotheranostics. Among the most studied systems, there are quantum dots, liposomes, polymeric nanoparticles, inorganic nanoparticles, magnetic nanoparticles, dendrimers, and gold nanoparticles. Most of the advantages of nanomaterials over the classic anticancer therapies come from their optimal size, which prevents the elimination by the kidneys and enhances their permeation in the tumor due to the abnormal blood vessels present in cancer tissues. Furthermore, the drug delivery and the contrast efficiency for imaging are enhanced, especially due to the increased surface area and the selective accumulation in the desired tissues. This property leads to the reduced drug dose necessary to exert the desired effect and for a longer action within the tumor. Finally, they are made so that there is no degradation into toxic byproducts and have a lower immune response triggering. In this article, we intend to review and discuss the state‐of‐the‐art regarding the use of nanomaterials as therapeutic and diagnostic tools for lung, breast, and prostate cancer, as they are among the most prevalent worldwide.