JORGE GABRIEL DOS SANTOS BATISTA
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Capítulo IPEN-doc 30885 Fungal nanobionics2023 - THIPE, VELAPHI C.; BATISTA, JORGE G.S.; LEBRE, DANIEL T.; LUGAO, ADEMAR B.; KATTI, KATTESH V.Fungi have proven to be one of the most beneficial microorganisms that have contributed and continue to play a pivotal role in human civilization. The nexus between mycology and nanotechnology provides a cornucopia of metabolites that can be utilized in nanotechnology to usher in a separate branch of study—"Myconanobiotechnology.” This is achieved by fungal nanobionics, which centers fungi as nanofactories for the large-scale industrial production of nanoparticles for the development of new next-generation products with industrial, agricultural, medicinal, and consumer application prospects in a wide range of sectors that stem from pharmaceuticals, agriculture, and energy, thus envisaging a completely different paradigm in relation to revolutionizing technologies. In this chapter, we cover a plethora of the biogenic-mediated synthesis of nanoparticles intracellularly and extracellularly with an in-depth understanding of the principles that govern fungal nanobionics. Furthermore, we provide an in-depth knowledge of the most recent advances in mycoinnovations that utilize fungal nanobionics in the ubiquitous role they play in a myriad of applications stemming from disinfectants, food packaging material additives, biosensors, medicine, cosmetics, textiles, electronics, composites, agricultural products (effective antimicrobial agents in nanofertilizers and nanopesticides), and most recently in energy through renewable, sustainable biofuel production.Capítulo IPEN-doc 29813 Fabrication of green nanomaterials2023 - THIPE, VELAPHI C.; FREITAS, LUCAS F.; LIMA, CAROLINE S.A.; BATISTA, JORGE G.S.; FERREIRA, ARYEL H.; OLIVEIRA, JUSTINE P.R. de; BALOGH, TATIANA S.; KADLUBOWSKI, SLAWOMIR; LUGAO, ADEMAR B.; KATTI, KATTESH V.The purpose of this chapter is to discuss the production of biocompatible green nanomaterials for biomedical applications using green nanotechnology. To enhance drug loading and delivery, these nanomaterials are engineered with immunomodulatory ligands such as phytochemicals (Epigallocatechin gallate, Mangiferin, Resveratrol), proteins (albumin and papain), crosslinked hydrogels, and nanogels. The nanomaterials described herein are synthesized via redox potential of electron-dense phytochemicals that reduce metallic precursors to their stable corresponding nanoparticles and via water radiolysis with ionizing radiation as a green approach (due to the absence of any reducing agent) for use as radiosensitizers (albumin and papain nanoparticles) in nuclear medicine – theranostics applications. The phytochemicals facilitate the delivery of nanoparticles through receptor mediated endocytosis, while the proteins such as papain, due to their proteolytic action enhances the permeation of nanoparticles into tumor tissue, and albumin increase the pharmacokinetic efficiency of these nanoparticles. The nanoparticles developed have shown effectiveness against a variety of human cancers while posing no toxicity to normal tissue. Additionally, a pilot human clinical combing Ayurvedic medicine with green nanomedicine is given as a novel approach for treating breast cancer and other related illnesses. Finally, the importance of ecotoxicology for nanomaterials is discussed in order to provide safety data in relevant multiple species (fish, daphnia, algae, rodents, etc.) with paratope/epitope distributions for evaluating tissue cross-reactivity profiles in human tissues and to provide critical information on in vivo toxicity in order to predict the possible adverse effects of nanomaterials on human and environmental health as an effort to establish regulatory limits and ISO standards for nanomaterials.