JORGE GABRIEL DOS SANTOS BATISTA
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Capítulo IPEN-doc 29813 Fabrication of green nanomaterials2023 - THIPE, VELAPHI C.; FREITAS, LUCAS F.; LIMA, CAROLINE S.A.; BATISTA, JORGE G.S.; FERREIRA, ARYEL H.; OLIVEIRA, JUSTINE P.R. de; BALOGH, TATIANA S.; KADLUBOWSKI, SLAWOMIR; LUGAO, ADEMAR B.; KATTI, KATTESH V.The purpose of this chapter is to discuss the production of biocompatible green nanomaterials for biomedical applications using green nanotechnology. To enhance drug loading and delivery, these nanomaterials are engineered with immunomodulatory ligands such as phytochemicals (Epigallocatechin gallate, Mangiferin, Resveratrol), proteins (albumin and papain), crosslinked hydrogels, and nanogels. The nanomaterials described herein are synthesized via redox potential of electron-dense phytochemicals that reduce metallic precursors to their stable corresponding nanoparticles and via water radiolysis with ionizing radiation as a green approach (due to the absence of any reducing agent) for use as radiosensitizers (albumin and papain nanoparticles) in nuclear medicine – theranostics applications. The phytochemicals facilitate the delivery of nanoparticles through receptor mediated endocytosis, while the proteins such as papain, due to their proteolytic action enhances the permeation of nanoparticles into tumor tissue, and albumin increase the pharmacokinetic efficiency of these nanoparticles. The nanoparticles developed have shown effectiveness against a variety of human cancers while posing no toxicity to normal tissue. Additionally, a pilot human clinical combing Ayurvedic medicine with green nanomedicine is given as a novel approach for treating breast cancer and other related illnesses. Finally, the importance of ecotoxicology for nanomaterials is discussed in order to provide safety data in relevant multiple species (fish, daphnia, algae, rodents, etc.) with paratope/epitope distributions for evaluating tissue cross-reactivity profiles in human tissues and to provide critical information on in vivo toxicity in order to predict the possible adverse effects of nanomaterials on human and environmental health as an effort to establish regulatory limits and ISO standards for nanomaterials.Capítulo IPEN-doc 28699 Cu and Cu-based nanomaterials as nanofungicides2022 - THIPE, VELAPHI C.; FREITAS, LUCAS F.; LIMA, CAROLINE S.A. de; NOGUEIRA, KAMILA M.; BATISTA, JORGE G.S.; FERREIRA, ARYEL H.; LUGAO, ADEMAR B.Green nanotechnology through the production of copper and copper oxide nanoparticles (CuNPs and CuONPs, respectively) as nanofungicides brings forth the opportunity attributed to their antimicrobial properties in addition to Cu being an essential metal micronutrient that functions as a cofactor for many enzymatic activities in plants. Herein, we explore the use of CuNPs and CuONPs as nanofungicides against toxigenic fungi and their mechanism of action. We also highlight the green nanoagriculture and the ecotoxicology and safety of CuNPs and CuONPs as nanofungicides to significantly aid as agricultural breakthroughs because such approaches will provide realistic sustainable nano Cu-enabled products deemed safe for agricultural practices.Capítulo IPEN-doc 28698 Copper nanomaterials for eliminating the risk of mycotoxins2022 - THIPE, VELAPHI C.; BATISTA, JORGE G.S.; LUGAO, ADEMAR B.Mycotoxins continue to pose significant challenges in agriculture and health sector. The most feasible strategy to eliminate their manifestation and risk is the use of fungicides against mycotoxigenic fungal contamination as an indirect approach. However, conventional fungicides have not been effectively attributed to acquired fungicide resistance and high toxicity on plants, animals, and human health. Copper (Cu) has been recognized as an essential micronutrient metal/mineral required by plants that participate in various physiological processes (chlorophyll and photosynthesis) and as a cofactor for enzymatic reactions including activation of many metalloproteins and those involved in lignin synthesis. Herein, we review Cu nanomaterials for the risk of mycotoxin also; we explore their nanofungicidal activity and the comprehensive understanding of the multitude of the tripartite interactions of Cu nanomaterials with the ecosystem (plants, soil, and animals/humans), and green nanotechnological approach in limiting their toxicity profile. Lately, we discuss some of the future recommendations for Cu nanofungicides toward eliminating the risk of mycotoxicology.Artigo IPEN-doc 28073 The state of the art of theranostic nanomaterials for lung, breast, and prostate cancers2021 - FREITAS, LUCAS F.; FERREIRA, ARYEL H.; THIPE, VELAPHI C.; VARCA, GUSTAVO H.C.; LIMA, CAROLINE S.A.; BATISTA, JORGE G.S.; RIELLO, FABIANE N.; NOGUEIRA, KAMILA; CRUZ, CASSIA P.C.; MENDES, GIOVANNA O.A.; RODRIGUES, ADRIANA S.; SOUSA, THAYNA S.; ALVES, VICTORIA M.; LUGAO, ADEMAR B.The synthesis and engineering of nanomaterials offer more robust systems for the treatment of cancer, with technologies that combine therapy with imaging diagnostic tools in the so‐called nanotheranostics. Among the most studied systems, there are quantum dots, liposomes, polymeric nanoparticles, inorganic nanoparticles, magnetic nanoparticles, dendrimers, and gold nanoparticles. Most of the advantages of nanomaterials over the classic anticancer therapies come from their optimal size, which prevents the elimination by the kidneys and enhances their permeation in the tumor due to the abnormal blood vessels present in cancer tissues. Furthermore, the drug delivery and the contrast efficiency for imaging are enhanced, especially due to the increased surface area and the selective accumulation in the desired tissues. This property leads to the reduced drug dose necessary to exert the desired effect and for a longer action within the tumor. Finally, they are made so that there is no degradation into toxic byproducts and have a lower immune response triggering. In this article, we intend to review and discuss the state‐of‐the‐art regarding the use of nanomaterials as therapeutic and diagnostic tools for lung, breast, and prostate cancer, as they are among the most prevalent worldwide.