MURILO ALISON VIGILATO

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Tem arquivos: true × Agência de fomento: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) ×

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    Artigo IPEN-doc 31132
    Comparing solution blow spinning and electrospinning methods to produce collagen and gelatin ultrathin fibers
    2024 - RODRIGUES, MURILO A.V.; BERTOLO, MIRELLA R.V.; HORN, MARILIA M.; LUGAO, ADEMAR B.; MATTOSO, LUIZ H.C.; PLEPIS, ANA M. de G.
    Ultrathin fibers have been used to design functional nanostructured materials for technological and biomedical applications. Combining the use of renewable and compatible sources with the emerging alternative SBS (solution blow spinning) technique opens new opportunities for material applications. In this review, we introduce the benefits of SBS over the classical electrospinning technique by following studies that use collagen or gelatin. SBS offers distinct advantages over electrospinning in the preparation of ultrathin fibers based on natural proteins, including the absence of high-voltage sources and the possibility of using fewer toxic solvents. Notably, there is also the prospect of using SBS directly in injured tissues, opening new strategies for in situ structure assembly SBS is a suitable approach to produce fibers at the nanoscale that can be tailored to distinct diameters by blending or simply adjusting experimental conditions. The focus on producing collagen or gelatin fibers contributes to designing highly biocompatible mats with potential for promoting cellular growth and implantation, even though their applications can be found also in food packaging, energy, and the environment. Therefore, a comprehensive analysis of the topic is essential to evaluate the current strategies regarding these materials and allow for their expanded production and advanced applications.
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    Artigo IPEN-doc 30910
    Advances in silver nanoparticles
    2024 - RODRIGUES, ADRIANA S.; BATISTA, JORGE G.S.; RODRIGUES, MURILO A.V.; THIPE, VELAPHI C.; MINARINI, LUCIENE A.R.; LOPES, PATRICIA S.; LUGAO, ADEMAR B.
    Nanoparticles play a crucial role in the field of nanotechnology, offering different properties due to their surface area attributed to their small size. Among them, silver nanoparticles (AgNPs) have attracted significant attention due to their antimicrobial properties, with applications that date back from ancient medicinal practices to contemporary commercial products containing ions or silver nanoparticles. AgNPs possess broad-spectrum biocidal potential against bacteria, fungi, viruses, and Mycobacterium, in addition to exhibiting synergistic effects when combined with certain antibiotics. The mechanisms underlying its antimicrobial action include the generation of oxygen-reactive species, damage to DNA, rupture of bacterial cell membranes and inhibition of protein synthesis. Recent studies have highlighted the effectiveness of AgNPs against various clinically relevant bacterial strains through their potential to combat antibiotic-resistant pathogens. This review investigates the proteomic mechanisms by which AgNPs exert their antimicrobial effects, with a special focus on their activity against planktonic bacteria and in biofilms. Furthermore, it discusses the biomedical applications of AgNPs and their potential non-preparation of antibiotic formulations, also addressing the issue of resistance to antibiotics.
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    Capítulo IPEN-doc 30888
    Copper-Based Nanomaterials for Biologically Relevant Compounds
    2024 - BATISTA, JORGE G. dos S.; RODRIGUES, MURILO A.V.; FREITAS, LUCAS F. de; FONSECA, ANA C.M.; RODRIGUES, ADRIANA de S.; CRUZ, CASSIA P.C. da; THIPE, VELAPHI C.; LUGAO, ADEMAR B.
    Copper-based nanomaterials have emerged as a new platform in various scientific domains due to their unique physicochemical, biological, and compatibility properties. This review explores the multifaceted applications of copper nanomaterials in the areas of biosensing, drug delivery, cancer therapy, and environmental remediation. The innovative role of copper nanomaterials in biosensors and their exceptional sensitivity and specificity in detecting biomolecules are discussed. Moreover, the potential applications of copper-based nanomaterials in drug delivery systems, highlighting the controlled and targeted release of therapeutic agents’ approaches are explored. In the domain of cancer theragnostic, copper nanomaterials exhibit promising results thus offering practical tools for early diagnosis and advanced treatment modalities. Furthermore, the antimicrobial properties of copper nanoparticles are explored, emphasizing their importance in combating microbial threats and promoting a new era in antimicrobial research. Copper-based nanomaterials could have a significant role in environmental and bioremediation applications. The strong catalytic activity of copper nanoparticles makes them ideal candidates for environmental remediation. In summary, this comprehensive review consolidates the latest advances in copper nanomaterials research, providing valuable information for scientists and researchers involved in diverse fields to promote the development of new applications and technologies.