Chitosan-tripolyphosphate (CS-TPP) nanoparticles containing naproxen (NPX) were dispersed in
poloxamer (PL) as unique (PL407) or binary (PL407-PL403) systems. Nanoparticles presented diameter
of 250nm and zeta potential of 35mV with drug loading and encapsulation efficiency of
98.4 ± 0.3% and 36.9 ± 0.12%, respectively. NPX-CS-TPP shifted the sol-gel transition and micellization
temperatures. PL407-PL403 systems presented G0 >G00 compared to PL407. SAXS patterns
revealed transitions from lamellar to hexagonal phase organizations with low drug release rates, in
the presence of CS-TPP nanoparticles. NPX-CS-TPP-PL407 induced lower cytotoxicity compared to
PL407-PL403 in fibroblasts and osteoblasts, making them promising systems for intra-articular
delivery.
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