RENATO ARAÚJO PRATES
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Resumo IPEN-doc 22998 Periodontal treatment combined to antimicrobial photodynamic therapy2017 - GODOY-MIRANDA, BIANCA; BELINELLO-SOUZA, ESTEFANI; ALVARENGA, LETICIA; LEAL, CINTIA; LEITE, CAROLINA; LIMA, TAIRINE; PREVIATI-OLIVEIRA, JHOSEPHER; FREITAS, ANDERSON; PRETTO, LUCAS de; FERNANDES, ADJACI; PRATES, RENATOBackground: Antimicrobial photodynamic therapy (APDT) has been used as an adjuvant treatment for periodontitis. It combines a photosensitizer (PS) with a light source to induce reactive oxygen species (ROS) and kill microbial cells. PpNetNI is a protoporphyrin derivate, and it has a chemical binding site at biofilm and great affinity to microbial cells. The aim of this study was to investigate the effects of APDT as an adjuvant treatment for periodontitis. Study: Ten healthy male rats Wistar (Rattus norvegicus) were used in this study (Approved by UNINOVE Ethical committee AN0029/2015). Periodontitis was induced by placing a cotton ligature around the first mandibular molar in a subgingival position. The contralateral mandibular first molar received neither a ligature nor any treatment, and was used as a control. After 7 days, the ligature was removed and all animals received scaling and root planning (SRP) and were divided according to the following treatments: SRP group (received SRP and irrigation with PpNetNI, 10 mM) and PDT group (PpNetNI 10 mM followed by LED irradiation). PDT was performed with a LED (630 nm) with an output power of 400mW (fluence-rate 200mW/cm2; fluence 18 J/cm2). Rats were euthanized at 7 days postoperatively. The bone loss was measured by Optical Coherence Tomography (OCT, THORLABS LTD., Newton, US). Data were analyzed statistically (Mann-Whitney test, p<0.05). in vestibular region of the first molar Results: The animals treated by APDT showed a bone gain of approximately 30% compared to the SRP group following 7 days from the treatment. OCT was able to detect bone loss in the samples and it was nondestructive method for this experimental model. Conclusion: In conclusion, within the parameters used in this study, APDT was an effective alternative to held periodontal health after treatment, and it was able to regenerate supportive periodontal tissue.Artigo IPEN-doc 15655 Photodynamic therapy on bacterial reduction in dental caries. In vivo study2010 - BAPTISTA, ALESSANDRA; PRATES, RENATO A.; KATO, ILKA T.; AMARAL, MARCELLO M.; FREITAS, ANDERSON Z. de; RIBEIRO, MARTHA S.Artigo IPEN-doc 15656 Real time optical coherence tomography monitoring of Candida albicans biofilm in vitro during photodynamic treatment2010 - SUZUKI, LUIS C.; PRATES, RENATO A.; RAELE, MARCUS P.; FREITAS, ANDERSON Z. de; RIBEIRO, MARTHA S.Artigo IPEN-doc 18040 Antimicrobial photodynamic therapy as a strategy to arrest enamel demineralization: a short-term study on incipient caries in a rat model2012 - BAPTISTA, ALESSANDRA; KATO, ILKA T.; PRATES, RENATO A.; SUZUKI, LUIS C.; RAELE, MARCUS P.; FREITAS, ANDERSON Z.; RIBEIRO, MARTHA S.