Effects of gamma irradiation on bovine bone microhardness and molecular structure
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2018
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ENCONTRO DE OUTONO, 41.
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The skeletal systems is a complex mixed compounds, organic and inorganic, that should present a mechanical
resistance to perform functions as protection of the vital organs and load distribution. Gamma radiation is
an ionizing radiation that comes from radioative sources or X-ray generator and it is commonly used in health
establishments such as radio diagnostic exams, radiotherapy and sterilization of allograft. The characterization
of the irradiated bone tissue can be an important tool in the study of the components that are aÆected and
how much each dose of ionizing radiation can alter its mechanical properties. This information will be very
important in in vitro and ex vivo studies where sterilization of the bone material is necessary and may still
be useful in understanding the eÆects on the bone tissue of patients undergoing short-term radiotherapy. For
this, 110 samples of bovine femur diaphysis were randomized into 11 groups: G1- untreated (control); G2 to
G11 were submitted to gamma irradiation (60Co Gammacel). Samples were polished before irradiation and
submitted to a Knoop Microhardness Test to determine the hardness of bovine bone and Fourier transform
Infrared spectroscopy (FTIR). Spectra were collected in the midinfrared range in Attenuated Total Reflectance
(ATR) sampling mode associated whit PCA multivariate technique to evaluate the molecular changes in bone
matrix. The microhardness analysis did not present a significant statistical diÆerence between the irradiated
and control groups, showing that ionizing radiation did not aÆect the mechanical structure of the samples, on
a micro scale. The results of FTIR with the PCA technique were eÆective in separating all groups, especially
those irradiated with doses of 0.002 kGy, 10 kGy and 35 kGy. We conclude that ATR-FTIR spectroscopy
associated with PCA is a good method to evaluate the biochemical changes promoted by ionizing radiation
in bone matrix. It was observed that hardness was not altered by gamma irradiation and FTIR spectroscopy
associated with PCA is a good method to analyze the changes in bone tissue submitted to ionizing radiation.
Como referenciar
DIAS, DERLY A.; PEREIRA, DAISA L.; GOMES, GABRIELA V.; SUGAHARA, VANESSA M.L.; ZAMATARO, CLAUDIA B.; ZEZELL, DENISE M.; MATHOR, MONICA B. Effects of gamma irradiation on bovine bone microhardness and molecular structure. In: ENCONTRO DE OUTONO, 41., 06-11 de maio, 2018, Foz do Iguaçu, PR. Resumo... São Paulo: Sociedade Brasileira de Física, 2018. p. 1-1. Disponível em: http://repositorio.ipen.br/handle/123456789/29826. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.