Fabrication of hyperbranched polyglycerols microcapsules from microfluidics guided by artificial neural networks
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2021
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BRAZIL MRS MEETING, 19th; INTERNATIONAL UNION OF MATERIALS RESEARCH SOCIETIES - INTERNATIONAL CONFERENCE ON ELECTRONIC MATERIALS
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Resumo
In recent years, the microfluidic approach has received a lot of attention from the scientific
community due to the simple and efficient synthesis of highly monodisperse microcapsules
used in a variety of applications in biotechnology and medicine such as, for example,
materials synthesis, drug encapsulation, among others [1,2]. Thus, in this work,
hyperbranched polyglycerol microcapsules (HPGM) were developed using microfluidic
technology. Artificial neural network (ANN) feed-forward using multilayer perceptron
architecture was trained and applied to model and predict the microfluidic process. The
HPGM produced were characterized by scanning electron microscope (SEM), attenuated
total reflection-Fourier transform infrared (ATR-FTIR) and thermogravimetric analysis
(TGA). The fabricated HPGM showed spherical size and monomodal distribution with an
average diameter of 29 μm. The developed ANN proved to be efficient predictor, showing
well agreement with the experimental data (R2=0.9983). Based on these results in this
research, it was found that the microfluidic device for producing HPGM was successfully
developed since it was possible to synthesize microcapsules with targeted properties,
monodispersed with high stability and low porosity. In this way, microfluidic technology
guided by ANN can be used to synthesize HPGM for biotechnology processes.
Como referenciar
ALVES, ANDRESSA A.; QUEIROZ, ÁLVARO A.A. de; QUEIROZ, ALFREDO A.A.E. de. Fabrication of hyperbranched polyglycerols microcapsules from microfluidics guided by artificial neural networks. In: BRAZIL MRS MEETING, 19th; INTERNATIONAL UNION OF MATERIALS RESEARCH SOCIETIES - INTERNATIONAL CONFERENCE ON ELECTRONIC MATERIALS, August 30 - September 3, 2021, Online. Abstract... São Carlos, SP: Aptor Software, 2021. p. 854-854. Disponível em: http://repositorio.ipen.br/handle/123456789/32833. Acesso em: 13 Mar 2025.
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