Evaluation of the use of sterilized and non-sterilized Peruibe Black Mud in patients with knee osteoarthritis

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dc.contributor.authorGOUVEA, PAULO F.M.pt_BR
dc.contributor.authorBRITSCHKA, ZELIA M.N.pt_BR
dc.contributor.authorGOMES, CRISTINA de O.M.S.pt_BR
dc.contributor.authorQUEIROZ, NICOLLE G.T. dept_BR
dc.contributor.authorSALVADOR, PABLO A.V.pt_BR
dc.contributor.authorSILVA, PAULO S.C.pt_BR
dc.coverageInternacionalpt_BR
dc.date.accessioned2021-07-12T18:51:53Z
dc.date.available2021-07-12T18:51:53Z
dc.date.issued2021pt_BR
dc.description.abstractThis study aimed to evaluate the effects of treatment with Peruíbe Black Mud (PBM) on the clinical parameters and quality of life of patients with knee osteoarthritis and to compare the effects of PBM samples simply matured in seawater and PBM sterilized by gamma radiation. A controlled, double-blind trial was conducted with 41 patients divided into two treatment groups composed of 20 and 21 patients: one group was treated with matured PBM and the other with sterilized PBM. Evaluations were done using theWestern Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and the Medical Outcomes Study Short Form 36 (SF-36) questionnaires, the Kellgren and Lawrence (KL) radiographic scale, and the quantification of the serum levels of inflammatory biomarkers. An improvement in pain, physical functions, and quality of life was observed in all of the patients who underwent treatment with both simply matured and sterilized PBM. Nine patients showed remission in the KL radiographic scale, but no statistically significant differences were observed in the serum levels of inflammatory mediators before or after treatment. Peruíbe Black Mud proves to be a useful tool as an adjuvant treatment for knee osteoarthritis (OA), as shown by the results of the WOMAC and SF-36 questionnaires and by the remission of the radiographic grade of some patients on the Kellgren and Lawrence scale.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipIDFAPESP: 12/16642-9pt_BR
dc.format.extent1-11pt_BR
dc.identifier.citationGOUVEA, PAULO F.M.; BRITSCHKA, ZELIA M.N.; GOMES, CRISTINA de O.M.S.; QUEIROZ, NICOLLE G.T. de; SALVADOR, PABLO A.V.; SILVA, PAULO S.C. Evaluation of the use of sterilized and non-sterilized Peruibe Black Mud in patients with knee osteoarthritis. <b>International Journal of Environmental Research and Public Health</b>, v. 18, n. 4, p. 1-11, 2021. DOI: <a href="https://dx.doi.org/10.3390/ijerph18041666">10.3390/ijerph18041666</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/32018.
dc.identifier.doi10.3390/ijerph18041666pt_BR
dc.identifier.fasciculo4pt_BR
dc.identifier.issn1660-4601pt_BR
dc.identifier.orcid0000-0003-4168-1626pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9351-9201
dc.identifier.orcidhttp://orcid.org/0000-0003-4168-1626
dc.identifier.percentilfi68.77pt_BR
dc.identifier.percentilfiCiteScore63.67
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/32018
dc.identifier.vol18pt_BR
dc.relation.ispartofInternational Journal of Environmental Research and Public Healthpt_BR
dc.rightsopenAccesspt_BR
dc.subjectbone joints
dc.subjecttherapy
dc.subjectclays
dc.subjectsensitivity analysis
dc.subjectabrasives
dc.titleEvaluation of the use of sterilized and non-sterilized Peruibe Black Mud in patients with knee osteoarthritispt_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorZELIA MARIA NOGUEIRA BRITSCHKA
ipen.autorPAULO SERGIO CARDOSO DA SILVA
ipen.autorPABLO ANTONIO VASQUEZ SALVADOR
ipen.autorPAULO FLAVIO DE MACEDO GOUVEA
ipen.codigoautor15944
ipen.codigoautor2777
ipen.codigoautor3075
ipen.codigoautor11267
ipen.contributor.ipenauthorZELIA MARIA NOGUEIRA BRITSCHKA
ipen.contributor.ipenauthorPAULO SERGIO CARDOSO DA SILVA
ipen.contributor.ipenauthorPABLO ANTONIO VASQUEZ SALVADOR
ipen.contributor.ipenauthorPAULO FLAVIO DE MACEDO GOUVEA
ipen.date.recebimento21-07
ipen.identifier.fi4.614pt_BR
ipen.identifier.fiCiteScore4.5
ipen.identifier.ipendoc27789pt_BR
ipen.identifier.iwosWoSpt_BR
ipen.range.fi4.500 - 5.999
ipen.range.percentilfi50.00 - 74.99
ipen.type.genreArtigo
relation.isAuthorOfPublicationc81181d8-0476-47a1-bb20-59366d866afb
relation.isAuthorOfPublicationaa898df6-ea14-482c-bc29-b45954bb0542
relation.isAuthorOfPublication47e9cd5a-dfda-4392-a887-42617e3c280f
relation.isAuthorOfPublicationb55d859a-1c66-473f-9761-e29ee13b7449
relation.isAuthorOfPublication.latestForDiscoveryb55d859a-1c66-473f-9761-e29ee13b7449
sigepi.autor.atividadeSILVA, PAULO S.C.:2777:310:Npt_BR
sigepi.autor.atividadeSALVADOR, PABLO A.V.:3075:240:Npt_BR
sigepi.autor.atividadeGOUVEA, PAULO F.M.:11267:-1:Spt_BR
sigepi.autor.atividadeBRITSCHKA, ZELIA M.N.:15944:-1:N
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