Mangiferin functionalized radioactive gold nanoparticles (MGF-198AuNPs) in prostate tumor therapy: green nanotechnology for production, in vivo tumor retention and evaluation of therapeutic efficacy
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We report here an innovative feature of green nanotechnology-focused work showing that mangiferin—a
glucose functionalized xanthonoid, found in abundance in mango peels—serves dual roles of chemical
reduction and in situ encapsulation, to produce gold nanoparticles with optimum in vivo stability and
tumor specific characteristics. The interaction of mangiferin with a Au-198 gold precursor affords
MGF-198AuNPs as the beta emissions of Au-198 provide unique advantages for tumor therapy while
gamma rays are used for the quantitative estimation of gold within the tumors and various organs. The
laminin receptor specificity of mangiferin affords specific accumulation of therapeutic payloads of this
new therapeutic agent within prostate tumors (PC-3) of human prostate tumor origin induced in mice
which overexpress this receptor subtype. Detailed in vivo therapeutic efficacy studies, through the intratumoral
delivery of MGF-198AuNPs, show the retention of over 80% of the injected dose (ID) in prostate
tumors up to 24 h. By three weeks post treatment, tumor volumes of the treated group of animals
showed an over 5 fold reduction as compared to the control saline group. New opportunities for green
nanotechnology and a new paradigm of using mangiferin as a tumor targeting agent in oncology for the
application of MGF-198AuNPs in the treatment of cancer are discussed.
Como referenciar
AL-YASIRI, A.Y.; KHOOBCHANDANI, M.; CUTLER, C.S.; WATKINSON, L.; CARMACK, T.; SMITH, C.J.; KUCHUK, M.; LOYALKA, S.K.; LUGAO, A.B.; KATTI, K.V. Mangiferin functionalized radioactive gold nanoparticles (MGF-198AuNPs) in prostate tumor therapy: green nanotechnology for production, in vivo tumor retention and evaluation of therapeutic efficacy. Dalton Transactions, 2017. DOI: 10.1039/c7dt00383h. Disponível em: http://repositorio.ipen.br/handle/123456789/27907. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.