Use of gamma-alumina nanoparticles for drug delivery system for releasing acyclovir
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2016
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INTERNATIONAL CONFERENCE ON DIFFUSION IN SOLIDS AND LIQUIDS, 12th
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Resumo
The sol-gel process is a method for preparing porous ceramics, vitreous and crystalline materials from
molecular precursors. In this process, a lattice of oxide compounds is made through reaction of inorganic
materials in aqueous solution. The sol-gel process may be used to produce nanoparticles of
pseudoboehmite, which are employed in drug delivery systems, production of nanocomposites and in the
synthesis of gamma-alumina [1,2,3]. The firing of pseudoboehmite produces pure gamma-alumina [4,5].
The use of nanoparticles in drug delivery systems is advantageous because it prevents repeated doses and
also decreases the amount of drug intake, which not only enhance the therapeutic effect, but also reduces
the risks of plasma concentration reaching toxic levels. The use of synthetic nanoparticles have attracted
great interest for applications in drug delivery systems. Pure gamma-alumina obtained from pseudoboehmite is a synthetic aluminum compound with excellent adsorbent properties. In this work,
gamma-alumina was obtained through pseudoboehmite firing to be used for in vitro release of acyclovir.
The gamma-alumina was characterized by X-ray diffraction (XRD), Differential Thermal Analysis (DTA),
Thermogravimetry Analysis (TG), Scanning Electron Microscopy (SEM) using secondary electron detector
and EDS detector. The release profile was obtained by UV/Vis spectroscopy for in vitro analysis. The results
indicate gamma-alumina is appropriate for release of acyclovir.
Como referenciar
MUNHOZ JUNIOR, A.H.; MIRANDA, L.F.; SILVA, L.G.A.; OLIVEIRA, M.O. de; ANDRADES, R.C.; GOMES, G.C. Use of gamma-alumina nanoparticles for drug delivery system for releasing acyclovir. In: INTERNATIONAL CONFERENCE ON DIFFUSION IN SOLIDS AND LIQUIDS, 12th, June 26-30, 2016, Split, Croatia. Abstract... p. 154-155. Disponível em: http://repositorio.ipen.br/handle/123456789/31248. Acesso em: 30 Dec 2025.
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