Role of substance P and bradykinin in acute pancreatitis induced by secretory phospholipase A2
Carregando...
Data
Data de publicação
Autores IPEN
Orientador
Título da Revista
ISSN da Revista
Título do Volume
É parte de
É parte de
É parte de
Pancreas
Exportar
Resumo
OBJECTIVES:: Secretory phospholipases A2 (sPLA2s) induce acute pancreatitis when injected into the common bile duct of rats. Substance P via neurokinin 1 (NK-1) receptors and bradykinin via B2 receptors are described to play important roles in the pathophysiology of acute pancreatitis. This study was undertaken to evaluate the role of substance P and bradykinin in the sPLA2-induced pancreatitis. METHODS:: Rats were submitted to the common bile duct injection of sPLA2 obtained from Naja mocambique mocambique venom at300 μg/kg. At 4 hours thereafter, measurement of pancreatic plasma extravasation, pancreatic and lung myeloperoxidase (MPO), serum amylase, and serum tumor necrosis factor α levels were evaluated. RESULTS:: Injection of sPLA2 significantly increased all parameters evaluated. Pretreatment with either the NK-1 receptor antagonist SR140333 or the B2 receptor antagonist icatibant largely reduced the increased pancreatic plasma extravasation and circulating levels of tumor necrosis factor α. Both treatments partly reduced the MPO levels in the pancreas, whereas in the lungs, icatibant was more efficient to reduce the increased MPO levels. In addition, icatibant largely reduced the serum levels of amylase, whereas SR140333 had no significant effect. CONCLUSIONS:: We concluded that NK-1 and B2 receptors can regulate important steps in the local and remote inflammation during acute pancreatitis induced by sPLA2.
Como referenciar
CAMARGO, ENILTON A.; FERREIRA, TATIANE; RIBELA, MARIA T.C.P.; NUCCI, GILBERTO de; LANDUCCI, ELEN C.T.; ANTUNES, EDSON. Role of substance P and bradykinin in acute pancreatitis induced by secretory phospholipase A2. Pancreas, v. 37, n. 1, p. 50-55, 2008. DOI: 10.1097/MPA.0b013e3185d9b9b. Disponível em: http://repositorio.ipen.br/handle/123456789/5036. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.