Cytogenetic effects of sup(131)I administered with recombinant human thyrotropin hormone (rec-hTSH) on blood lymphocyte of Wistar rat
Carregando...
Data
Data de publicação
2004
Orientador
Título da Revista
ISSN da Revista
Título do Volume
É parte de
É parte de
É parte de
É parte de
BRAZILIAN CONGRESS OF NUCLEAR MEDICINE, 22nd
Exportar
Resumo
The large application of '*'| for diagnostic and therapeutic purposes is
essentially due to its preferential thyroid uptake, which is related to the
gland activity in physiological and pathological thyroid conditions. Despite
the recognized efficacy of various radionuclides used in nuclear medicine,
there is little information about the cytogenetic effects of beta emitter
radionuclides. The aim of the present study is to analyze the cytogenetic
effect of '*| preceded by the administration of recombinant human
thyrotropin hormone (rec-hTSH produced by IPEN - CNEN/SP) in animal
model, using the chromosome aberration technique. Rec-hTSH is a
glycoprotein administered in patients submitted to thyroidectomy as an
alternative to thyroid hormone withdrawal in order to increase TSH level
and, consequently, '5'| uptake by metastatic tissue, still maintaining their
euthyroid condition and quality of life. There are no data about the
cytogenetic effect of prolonged exposure to '3'| preceded by rec-hTSH in
animal as well as in human being. Wistar rats (SPF females, weighing ~
200 g) were divided in two groups: one group of animals was treated with
31| only (11.1 MBq, by gavage) and the other group received rec-hTSH
(1.2 microg, by intramuscularly injection) 24h before the administration of
13!|, The blood samples were collected via orbital plex before the
treatments (basal), 24 hours and 7 days later. The cytogenetic analysis
showed an increase in chromosome aberration 24 hours and 7 days after
the administration of '%'1 with or without rec-hTSH, compared to basal values, although the difference was not found significant (p>0.05). There
was also no difference (p>0.05) between the chromosome aberration rate
in blood samples collected after the administration of *'l only and those
preceded by rec-hTSH. The use of an animal model can provide important
informations about the relation between the therapeutic exposure to the
radionuclide and its genotoxic potential.
Como referenciar
SILVA, M.A.; SUZUKI, M.F.; GUIMARAES, M.I.C.C.; BUCHPIGUEL, C.A.; RIBELA, M.T.C.P.; BARTOLINI, P.; OKAZAKI, K. Cytogenetic effects of sup(131)I administered with recombinant human thyrotropin hormone (rec-hTSH) on blood lymphocyte of Wistar rat. In: BRAZILIAN CONGRESS OF NUCLEAR MEDICINE, 22nd, 9-12 Oct, 2004, Aracaju, PE. Abstract... Disponível em: http://repositorio.ipen.br/handle/123456789/19921. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.