Development of advanced scaffolds and polymeric systems for improved cell and tissue growth

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dc.contributor.authorKLINGBEIL, M.
dc.contributor.authorERNESTO, J.
dc.contributor.authorLOPES, P.
dc.contributor.authorROCHA, D.
dc.contributor.authorOLIVEIRA, J.
dc.contributor.authorVARCA, G.H.C.
dc.contributor.authorSILVA, C.
dc.contributor.authorSTEFFENS, D.
dc.contributor.authorLUGAO, A.B.
dc.contributor.authorMATHOR, M.
dc.coverageInternacionalpt_BR
dc.creator.eventoINTERNATIONAL CONFERENCE ON APPLICATIONS OF RADIATION SCIENCE AND TECHNOLOGYpt_BR
dc.date.accessioned2017-09-22T12:23:31Z
dc.date.available2017-09-22T12:23:31Z
dc.date.eventoApril 24-28, 2017pt_BR
dc.description.abstractThe recent concern related to skin compromised patients, apart from the nature of the condition itself, such as wounds, chronic ulcers, or burns among others, has triggered and highlighted the importance of the development of artificial skins available in allogeneic donor tissue banks and/or scaffolds, composed by a wide variety of biocompatible, biodegradable and bioactive biomaterials. Within this context, tissue engineering has been in expansion as an attempt to overcome difficulties faced in such situations. The application of scaffolds, produced or not by nanotechnology, in the skin of a patient induces cells to proliferate and get organized on extracellular matrix regenerating tissue. Ionizing radiation is a particularly useful technology capable of promoting sterilization and cross-linking of the scaffold structure thus offering several possibilities for the development of advanced systems suitable for cell growth. Taking into account the variety of clinical applications of tissue engineering, the aim of this study was to investigate by means of histological tests, chemistries and non-destructive tests, the interaction of mesenchymal stem cells grown in vitro in conjunction with different frameworks in order to understand how the mesenchymal stem cells behave in different niches. Among those collagen, PVA, chitosan, PDLLA scaffolds were the systems of choice and -irradiation was applied for sterilization of the systems, as well as cross-linking for the PVA based scaffold. Thus this work allowed the achievement of dermo-epidermic matrices populated by epidermal cells that make up the skin and will contribute to the development of a more robust and useful material to be used in several treatments.pt_BR
dc.event.siglaICARSTpt_BR
dc.format.extent381-381pt_BR
dc.identifier.citationKLINGBEIL, M.; ERNESTO, J.; LOPES, P.; ROCHA, D.; OLIVEIRA, J.; VARCA, G.H.C.; SILVA, C.; STEFFENS, D.; LUGAO, A.B.; MATHOR, M. Development of advanced scaffolds and polymeric systems for improved cell and tissue growth. In: INTERNATIONAL CONFERENCE ON APPLICATIONS OF RADIATION SCIENCE AND TECHNOLOGY, April 24-28, 2017, Vienna, Austria. <b>Abstract...</b> Vienna: IAEA, 2017. p. 381-381. Disponível em: http://repositorio.ipen.br/handle/123456789/27778.
dc.identifier.orcidhttp://orcid.org/0000-0002-7294-9106
dc.identifier.orcidhttps://orcid.org/0000-0002-1737-3191
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/27778
dc.localViennapt_BR
dc.local.eventoVienna, Austriapt_BR
dc.publisherIAEApt_BR
dc.rightsopenAccesspt_BR
dc.titleDevelopment of advanced scaffolds and polymeric systems for improved cell and tissue growthpt_BR
dc.typeResumo de eventos científicospt_BR
dspace.entity.typePublication
ipen.autorPATRICIA LOPES
ipen.autorDANILO PIGNATA ROCHA
ipen.autorMONICA BEATRIZ MATHOR
ipen.autorADEMAR BENEVOLO LUGAO
ipen.autorGUSTAVO HENRIQUE COSTAVARCA
ipen.autorJUSTINE PAULA RAMOS DE OLIVEIRA
ipen.autorMARIA FATIMA GUARIZO KLINGBEIL
ipen.codigoautor12162
ipen.codigoautor14276
ipen.codigoautor209
ipen.codigoautor339
ipen.codigoautor8661
ipen.codigoautor8726
ipen.codigoautor3309
ipen.contributor.ipenauthorPATRICIA LOPES
ipen.contributor.ipenauthorDANILO PIGNATA ROCHA
ipen.contributor.ipenauthorMONICA BEATRIZ MATHOR
ipen.contributor.ipenauthorADEMAR BENEVOLO LUGAO
ipen.contributor.ipenauthorGUSTAVO HENRIQUE COSTAVARCA
ipen.contributor.ipenauthorJUSTINE PAULA RAMOS DE OLIVEIRA
ipen.contributor.ipenauthorMARIA FATIMA GUARIZO KLINGBEIL
ipen.date.recebimento17-09pt_BR
ipen.event.datapadronizada2017pt_BR
ipen.identifier.ipendoc23066pt_BR
ipen.notas.internasAbstractpt_BR
ipen.type.genreResumo
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relation.isAuthorOfPublication.latestForDiscovery3a897c37-704e-494e-bb54-795b1d56554d
sigepi.autor.atividadeKLINGBEIL, M.:3309:230:Spt_BR
sigepi.autor.atividadeLOPES, P.:12162:230:Npt_BR
sigepi.autor.atividadeROCHA, D.:14276:230:Npt_BR
sigepi.autor.atividadeOLIVEIRA, J.:8726:740:Npt_BR
sigepi.autor.atividadeVARCA, G.H.C.:8661:750:Npt_BR
sigepi.autor.atividadeLUGAO, A.B.:339:740:Npt_BR
sigepi.autor.atividadeMATHOR, M.:209:240:Npt_BR
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