Evaluation of acute toxicity in the treatment of prostate cancer with conformational radiotherapy
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2019
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INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE
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Resumo
BACKGROUND: Radiatiotherapy is often associated with a wide range of significant side effects. These side
effects are commonly classified as acute or delayed according to when they manifest in relation to treatment.
METHODS: This study aimed to evaluate acute toxicity in patients with prostate cancer treated with
conformational radiotherapy (3D) in an Oncology Unit in Eastern Minas Gerais. A prospective,
observational, cohort study was performed through a non-probabilistic sampling of convenience, totalazing 45
patients. Patients included in the study were followed from the start of treatment to 3 months after external
beam radiation therapy (EBRT). RESULTS: Demographic Characteristics - Of the 45 patients included, mean
age was 70.6 ± 8.3 (SD) years, and predominantly white (44.0 %). The majority were married (75.6 %).
Considering the risk classification, there was a homogeneous distribution between the low (33.3 %),
intermediate (31.1 %) and high (35.6 %) levels. The majority of the patients (57.8 %) had a low risk (T1)
classification, followed by intermediate risk classification (33.3%) and high risk (8.9 %). In the Gleason score,
44.4 % presented values below 6 (low), 40.0 % intermediate, and 15.5 % high. 62.2 % had a PSA level less than
10 ng.mL-1, 22.2 % had an intermediate level, from 10 to 20 ng.mL-1 and 15.6%, above 20 ng.mL-1.
Manifestation of acute toxicity - It was observed that the majority (59.1 %) of the acute effects manifested
during the first consultation, prevailing the symptom of urinary frequency (64.1 %). Regarding the symptoms of
acute effects most prevalent during the three consultations, we highlight the urinary frequency with 44.0 %,
followed by the urinary residue (20.0 %). CONCLUSION: 80.0 % of the patients presented acute effects
during radiotherapy, being the urinary frequency the event more frequent (44.0 %), followed by urinary residue
(20.0 %). Eighteen patients (40.0 %) presented only one acute effect and 59.1 % of the effects were observed at
the first visit.
Como referenciar
CARLECH, HIGOR S.; LISBOA, ANA C.V.C.; VITAL, MARCILIO L.; ZEITUNI, CARLOS A.; ROSTELATO, MARIA E.C.M. Evaluation of acute toxicity in the treatment of prostate cancer with conformational radiotherapy: choort with 45 patients. In: INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE, October 21-25, 2019, Santos, SP. Proceedings... Rio de Janeiro: Associação Brasileira de Energia Nuclear, 2019. p. 1797-1809. Disponível em: http://repositorio.ipen.br/handle/123456789/30584. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.