Radiolytic degradation of levonorgestrel and gestodene

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dc.contributor.authorJESUS, JULIANA M.S. dept_BR
dc.contributor.authorTOMINAGA, FLAVIO K.pt_BR
dc.contributor.authorARGOLO, ALLAN dos S.pt_BR
dc.contributor.authorNASCIMENTO, ANA C.G.pt_BR
dc.contributor.authorBORRELY, SUELI I.pt_BR
dc.contributor.authorVIEIRA, DANIEL P.pt_BR
dc.contributor.authorBILA, DANIELE M.pt_BR
dc.contributor.authorTEIXEIRA, ANTONIO C.S.C.pt_BR
dc.coverageInternacionalpt_BR
dc.date.accessioned2022-08-12T14:34:32Z
dc.date.available2022-08-12T14:34:32Z
dc.date.issued2022pt_BR
dc.description.abstractThis study reports the feasibility of ionizing sources (60Co source and electron beam radiation) to degrade the progestins hormones levonorgestrel (LNG) and gestodene (GES) in synthetic solutions and real pharmaceutical wastewater (RPW). Doses of 0.5–100 kGy and dose rates of 2.5 and 10 kGy h−1 were applied. LNG was shown to be more recalcitrant than GES, with 90% removals achieved at doses around 7.7 kGy (LNG) and 1.6 kGy (GES) in model systems, with LNG showing greater reactivity with reducing species in γ-radiolyis, unlike GES. Furthermore, LNG removal remained around 60% in RPW at low doses, while more than 60% GES removal was observed for all doses. LNG and GES toxicities to Daphnia similis were absorbed dose-dependent, with low doses resulting in toxicity reductions of around 32% (LNG) and 42% (GES); in turn, high doses promoted a fourfold increase in toxicity. γ-radiolysis reduced the cytotoxic character of LNG to NIH-3T3-L1 cells, while non-irradiated or irradiated GES solutions did not exhibit any cytotoxic effect. Finally, the estrogenic activity, evaluated by the YES assay, was dose-dependent for both progestins, which may be related to the evolution of transformation products formed by water radiolysis in each case, decreasing for high doses.pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipIDCAPES: 001; 88887.340964/2019-00pt_BR
dc.description.sponsorshipIDCNPq: 311230/2020-2pt_BR
dc.format.extent520-530pt_BR
dc.identifier.citationJESUS, JULIANA M.S. de; TOMINAGA, FLAVIO K.; ARGOLO, ALLAN dos S.; NASCIMENTO, ANA C.G.; BORRELY, SUELI I.; VIEIRA, DANIEL P.; BILA, DANIELE M.; TEIXEIRA, ANTONIO C.S.C. Radiolytic degradation of levonorgestrel and gestodene: performance and bioassays. <b>Process Safety and Environmental Protection</b>, v. 162, p. 520-530, 2022. DOI: <a href="https://dx.doi.org/10.1016/j.psep.2022.04.021">10.1016/j.psep.2022.04.021</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/33204.
dc.identifier.doi10.1016/j.psep.2022.04.021pt_BR
dc.identifier.issn0957-5820pt_BR
dc.identifier.orcid0000-0002-0007-534Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0007-534X
dc.identifier.orcidhttps://orcid.org/0000-0002-9692-5539
dc.identifier.percentilfi85.3pt_BR
dc.identifier.percentilfiCiteScore90pt_BR
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/33204
dc.identifier.vol162pt_BR
dc.relation.ispartofProcess Safety and Environmental Protectionpt_BR
dc.rightsopenAccesspt_BR
dc.subjectdrugs
dc.subjecthormones
dc.subjectprogesterone
dc.subjectwaste water
dc.subjectgasers
dc.subjectelectron beams
dc.subjectradiolysis
dc.titleRadiolytic degradation of levonorgestrel and gestodenept_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorANA CRISTINA GOMES NASCIMENTO
ipen.autorDANIEL PEREZ VIEIRA
ipen.autorSUELI IVONE BORRELY
ipen.autorFLAVIO KIYOSHI TOMINAGA
ipen.codigoautor14753
ipen.codigoautor3158
ipen.codigoautor150
ipen.codigoautor12754
ipen.contributor.ipenauthorANA CRISTINA GOMES NASCIMENTO
ipen.contributor.ipenauthorDANIEL PEREZ VIEIRA
ipen.contributor.ipenauthorSUELI IVONE BORRELY
ipen.contributor.ipenauthorFLAVIO KIYOSHI TOMINAGA
ipen.date.recebimento22-08
ipen.identifier.fi7.8pt_BR
ipen.identifier.fiCiteScore10.8pt_BR
ipen.identifier.ipendoc28860pt_BR
ipen.identifier.iwosWoSpt_BR
ipen.identifier.ods6
ipen.range.fi6.000 ou mais
ipen.range.percentilfi75.00 - 100.00
ipen.subtituloperformance and bioassayspt_BR
ipen.type.genreArtigo
relation.isAuthorOfPublication12fd2681-92ad-4683-94d0-243825b4a97a
relation.isAuthorOfPublicationc2352608-be9c-4a73-be8c-571f10bb53d2
relation.isAuthorOfPublication76171e20-c8ac-475f-9006-27402113c92f
relation.isAuthorOfPublicationaa4a15b8-4ad7-4bb6-a280-c0de5cf947d6
relation.isAuthorOfPublication.latestForDiscoveryaa4a15b8-4ad7-4bb6-a280-c0de5cf947d6
sigepi.autor.atividadeVIEIRA, DANIEL P.:3158:810:Npt_BR
sigepi.autor.atividadeBORRELY, SUELI I.:150:220:Npt_BR
sigepi.autor.atividadeNASCIMENTO, ANA C.G.:14753:810:Npt_BR
sigepi.autor.atividadeTOMINAGA, FLAVIO K.:12754:220:Npt_BR
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