Processing, characterization, and in vitro/in vivo evaluations of powder metallurgy processes Ti-13Nb-13Zr alloys
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JOSE CARLOS BRESSIANI
ANA HELENA DE ALMEIDA BRESSIANI
OLGA ZAZUCO HIGA
MARCO CICERO MARTINS BOTTINO
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Journal of Biomedical Materials Research, A
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This article presents details of processing, characterization and in vitro as well as in vivo evaluations of powder metallurgy processed Ti-13Nb-13Zr samples with different levels of porosity. Sintered samples were characterized for density, crystalline phases (XRD), and microstructure (SEM and EDX). Samples sintered at 1000°C showed the highest porosity level (∼30%), featuring open and interconnected pores ranging from 50 to 100 μm in diameter but incomplete densification. In contrast, samples sintered at 1300 and 1500°C demonstrated high densification with 10% porosity level distributed in a homogeneous microstructure. The different sintering conditions used in this study demonstrated a coherent trend that is increase in temperature lead to higher sample densification, even though densification represents a drawback for bone ingrowth. Cytotoxicity tests did not reveal any toxic effects of the starting and processed materials on surviving cell percentage. After an 8-week healing period in rabbit tibias, the implants were retrieved, processed for nondecalcified histological evaluation, and then assessed by backscattered electron images (BSEI-SEM) and EDX. Bone growth into the microstructure was observed only in samples sintered at 1000°C. Overall, a close relation between newly formed bone and all processed samples was observed.
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BOTTINO, MARCO C.; COELHO, PAULO G.; HENRIQUES, VINICIUS A.R.; HIGA, OLGA Z.; BRESSIANI, ANA H.A.; BRESSIANI, JOSE C. Processing, characterization, and in vitro/in vivo evaluations of powder metallurgy processes Ti-13Nb-13Zr alloys. Journal of Biomedical Materials Research, A, v. 88A, p. 689-696, 2009. DOI: 10.1002/jbm.a.31912. Disponível em: http://repositorio.ipen.br/handle/123456789/4896. Acesso em: 01 Sep 2026.
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