Gold nanoparticles synthetized with aminolevulinic acid for theranostic
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2017
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PAN AMERICAN CONGRESS OF NANOTECHNOLOGY, 1st; FUNDAMENTALS AND APPLICATIONS TO SHAPE THE FUTURE
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In this study we propose to synthesize gold nanoparticles with 5-ALA, to study cytotoxicity in cell cultures,
to perform photodynamic (PDT) and sonodynamic (SDT) therapies and to compare the efficience of 5-ALA delivery.
For 5-ALA:AuNPs synthesis, is used a 300 Watt Xenon lamp for photo reduction. Cytotoxicity tests were performed
on 96-well plates with THP-1 human cells, which were differentiated into macrophages. For the PDT, an amber LED
at 590 nm (~ 100mW) was used for 2 minutes and SDT was used with pulses of 1 MHz and 1W / cm2, for 2 minutes.
Cellular viability assays (MTS) were performed to evaluate therapies. The results have shown improved photosensitizer
delivery in cells incubated with 5-ALA:AuNPs, leading to cell death and indicating potential use as a photo and
sonosensitizer agent.
Como referenciar
GONÇALVES, KARINA O.; BONFIM, LETICIA; VIEIRA, DANIEL P.; COURROL, LILIA C. Gold nanoparticles synthetized with aminolevulinic acid for theranostic: photodynamic and sonodynamic therapies. In: PAN AMERICAN CONGRESS OF NANOTECHNOLOGY, 1st; FUNDAMENTALS AND APPLICATIONS TO SHAPE THE FUTURE, November 27-30, 2017, Guarujá, SP. Proceedings... Disponível em: http://repositorio.ipen.br/handle/123456789/28432. Acesso em: 27 Mar 2026.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.