Radiation-induced "one pot" synthesis for cell therapies

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dc.contributor.authorLUGAO, ADEMAR B.
dc.contributor.authorFAZOLIN, GABRIELA N.
dc.contributor.authorVARCA, GUSTAVO H.C.
dc.contributor.authorSANTOS, JORGE G.
dc.contributor.authorBARROS, JANAINA
dc.contributor.authorFUCASE, TAMARA
dc.contributor.authorSANTOS, JONNATAN J.
dc.contributor.authorLEAL, JESSICA
dc.contributor.authorGRASSELLI, MARIANO
dc.contributor.authorKATTI, KATTESH V.
dc.coverageInternacionalpt_BR
dc.creator.eventoPAN AMERICAN CONGRESS OF NANOTECHNOLOGY, 1stpt_BR
dc.date.accessioned2018-08-13T13:18:51Z
dc.date.available2018-08-13T13:18:51Z
dc.date.evento27-30 de novembro, 2017pt_BR
dc.description.abstractThe dream of Marie Curie lab’s expressed by Regaud and Lacassagne in 1927 was to administer radiations with penetration range of molecular dimensions to the organism and selectively fixed in the protoplasm of cells one seeks to destroy. Gold nanoparticles can be employed as a radiation sensitizer by utilizing mainly Auger effect and photoelectrons. Auger electrons are released in large numbers with low kinetic energy therefore these electrons damage cells over a very short range: less than the size of a single cell, on the order of nanometers. Gold-198 is a beta and gamma emitter can be employed for therapy as well as diagnostic. The radioactive properties of gold include: Au (βmax=0.96 MeV; t1/2 = 2.7 days) and Au (βmax =0.46 MeV; t1/2 = 3.14 days), making it a strong candidate for theranostics. However, Gold or Gold-198 need to internalize selectively in tumor cells. Conjugation with proteins and peptides can make them very selective. While radioactive nanoparticles can offer a much higher dose payload than ions for therapy and diagnostic, in addition to the huge surface to bind targeting species presented by the nanoparticles, functionalization with proteins may potentially increases the particle uptake by tumors or tissues. Albumin and Papain features a set of characteristics that assure applications as natural drug carriers with particular attractive properties in oncology. Albumin may be easily crosslinked and engineered towards loading of large number of hydrophobic molecules as well as hydrophilic ones. They can be bound in a reversible way and the delivery controlled by endogenous mechanism. Alternatively to conventional systems, albumin can be crosslinked by radiation in such way that dialdehydes or toxic chemicals are totally avoided . Conjugation of such materials with sugars, peptides, antibodies, proteins among others is routinely used nowadays for targeting. The main purpose of this work was the development of one pot in situ synthesis of radioactive gold 198 nanoparticle encapsulated by albumin for application in cancer Theranostics. While crosslinked albumin may provide a nontoxic coating on AuNPs with a controllable hydrodynamic diameter, conventional AuNP can be activated by nuclear reactor to produce AuNP. The gamma or beta radiation originated from the gold nanoparticle was used to crosslink the Albumin layer. The use of a radioactive particle able to emit radiation for crosslinking of the Albumin layer and simultaneous theranostic application was tried for the first time. The elegant procedure and simplicity of the production process combined with the properties of Au and the safety of AuNP/BSA make this new particle an exciting advancement in cancer therapy and diagnosis. Gold conjugated protein nanoparticles and protein nanoparticles itself were also produced in an radiation induced one pot process. Crosslinking and protein damage werea cessed by different techniques.pt_BR
dc.event.siglaPANNANOpt_BR
dc.identifier.citationLUGAO, ADEMAR B.; FAZOLIN, GABRIELA N.; VARCA, GUSTAVO H.C.; SANTOS, JORGE G.; BARROS, JANAINA; FUCASE, TAMARA; SANTOS, JONNATAN J.; LEAL, JESSICA; GRASSELLI, MARIANO; KATTI, KATTESH V. Radiation-induced "one pot" synthesis for cell therapies. In: PAN AMERICAN CONGRESS OF NANOTECHNOLOGY, 1st, 27-30 de novembro, 2017, Guarujá, SP. <b>Abstract...</b> Disponível em: http://repositorio.ipen.br/handle/123456789/29043.
dc.identifier.orcidhttps://orcid.org/0000-0002-1737-3191
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/29043
dc.local.eventoGuarujá, SPpt_BR
dc.rightsopenAccesspt_BR
dc.titleRadiation-induced "one pot" synthesis for cell therapiespt_BR
dc.typeResumo de eventos científicospt_BR
dspace.entity.typePublication
ipen.autorGABRIELA NEMESIO FAZOLIN
ipen.autorJORGE GABRIEL DOS SANTOS BATISTA
ipen.autorJANAINA ALINE GALVÃO BARROS
ipen.autorJONNATAN JULIVAL DOS SANTOS
ipen.autorJESSICA LEAL
ipen.autorTAMARA MIECO FUCASE
ipen.autorGUSTAVO HENRIQUE COSTAVARCA
ipen.autorADEMAR BENEVOLO LUGAO
ipen.codigoautor14241
ipen.codigoautor10274
ipen.codigoautor14272
ipen.codigoautor14395
ipen.codigoautor11679
ipen.codigoautor8724
ipen.codigoautor8661
ipen.codigoautor339
ipen.contributor.ipenauthorGABRIELA NEMESIO FAZOLIN
ipen.contributor.ipenauthorJORGE GABRIEL DOS SANTOS BATISTA
ipen.contributor.ipenauthorJANAINA ALINE GALVÃO BARROS
ipen.contributor.ipenauthorJONNATAN JULIVAL DOS SANTOS
ipen.contributor.ipenauthorJESSICA LEAL
ipen.contributor.ipenauthorTAMARA MIECO FUCASE
ipen.contributor.ipenauthorGUSTAVO HENRIQUE COSTAVARCA
ipen.contributor.ipenauthorADEMAR BENEVOLO LUGAO
ipen.date.recebimento18-08pt_BR
ipen.event.datapadronizada2017pt_BR
ipen.identifier.ipendoc24835pt_BR
ipen.notas.internasAbstractpt_BR
ipen.type.genreResumo
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relation.isAuthorOfPublication.latestForDiscovery99ac24c5-2ae1-465a-a6f2-40b4d9af6af7
sigepi.autor.atividadeLUGAO, ADEMAR B.:339:740:Spt_BR
sigepi.autor.atividadeFAZOLIN, GABRIELA N.:14241:740:Npt_BR
sigepi.autor.atividadeVARCA, GUSTAVO H.C.:8661:750:Npt_BR
sigepi.autor.atividadeSANTOS, JORGE G.:10274:740:Npt_BR
sigepi.autor.atividadeBARROS, JANAINA:14272:740:Npt_BR
sigepi.autor.atividadeFUCASE, TAMARA:8724:-1:Npt_BR
sigepi.autor.atividadeSANTOS, JONNATAN J.:14395:740:Npt_BR
sigepi.autor.atividadeLEAL, JESSICA:11679:740:Npt_BR
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