Synthesis of polymeric hydrogel loaded with antibiotic drug for wound healing applications

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dc.contributor.authorZAFALON, ANGELICA T.
dc.contributor.authorSANTOS, VINICIUS J. dos
dc.contributor.authorESPOSITO, FERNANDA
dc.contributor.authorLINCOPAN, NILTON
dc.contributor.authorRANGARI, VIJAYA
dc.contributor.authorLUGAO, ADEMAR B.
dc.contributor.authorPARRA, DUCLERC F.
dc.contributor.editorLI, BOWEN
dc.contributor.editorLI, JIAN
dc.contributor.editorIKHMAYIES, SHADIA
dc.contributor.editorZHANG, MINGMING
dc.contributor.editorKALAY, YUNUS E.
dc.contributor.editorCARPENTER, JOHN S.
dc.contributor.editorHWANG, JIANN-YANG
dc.contributor.editorMONTEIRO, SERGIO N.
dc.contributor.editorFIRRAO, DONATO
dc.contributor.editorBROWN, ANDREW
dc.contributor.editorBAI, CHENGUANG
dc.contributor.editorPENG, ZHIWEI
dc.contributor.editorESCOBEDO-DIAZ, JUAN P.
dc.contributor.editorGOSWAMI, RAMASIS
dc.contributor.editorKIM, JEONGGUK
dc.coverageInternacionalpt_BR
dc.date.accessioned2018-04-24T15:32:20Z
dc.date.available2018-04-24T15:32:20Z
dc.date.issued2018pt_BR
dc.description.abstractPolymeric hydrogels are natural or synthetic systems, which have gained interest due to their high biocompatibility with soft tissues. These types of hydrogels have been used for wound dressing as a drug delivery system. Here in this study the polymeric hydrogels based wound healing systems were prepared using poly (N-vinyl-2-pyrrolidone) (PVP), poly (ethylene glycol) (PEG), agar and neomycin drug followed by gamma irradiation to promote crosslinking and sterilization. The influence of irradiation process with 25 kGy dose was investigated. The gel fraction and maximum swelling were estimated using physicochemical methods and found about 95% gel fraction and 1100% swelling after 8 h of immersion. Neomycin released from hydrogel was carried out by Liquid Chromatography-Mass Spectrometry method and the drug concentration remained constant for 48 h. Hydrogel/neomycin exhibited antibacterial effects against Staphylococcus aureus. With these results, it can be inferred that hydrogel/neomycin is a suitable candidate for wound dressing.pt_BR
dc.format.extent165-176pt_BR
dc.identifier.citationZAFALON, ANGELICA T.; SANTOS, VINICIUS J. dos; ESPOSITO, FERNANDA; LINCOPAN, NILTON; RANGARI, VIJAYA; LUGAO, ADEMAR B.; PARRA, DUCLERC F. Synthesis of polymeric hydrogel loaded with antibiotic drug for wound healing applications. In: LI, BOWEN (ed.); LI, JIAN (ed.); IKHMAYIES, SHADIA (ed.); ZHANG, MINGMING (ed.); KALAY, YUNUS E. (ed.); CARPENTER, JOHN S. (ed.); HWANG, JIANN-YANG (ed.); MONTEIRO, SERGIO N. (ed.); FIRRAO, DONATO (ed.); BROWN, ANDREW (ed.); BAI, CHENGUANG (ed.); PENG, ZHIWEI (ed.); ESCOBEDO-DIAZ, JUAN P. (ed.); GOSWAMI, RAMASIS (ed.); KIM, JEONGGUK (ed.). <b>Characterization of Minerals, Metals, and Materials. TMS</b>. Cham, CZ, Switzerland: Springer International Publishing AG., 2018. p. 165-176. (The Minerals, Metals & Materials Series). DOI: <a href="https://dx.doi.org/10.1007/978-3-319-72484-3_18">10.1007/978-3-319-72484-3_18</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/28873.
dc.identifier.doi10.1007/978-3-319-72484-3_18pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7626-880X
dc.identifier.orcidhttps://orcid.org/0000-0002-1737-3191
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/28873
dc.localCham, CZ, Switzerlandpt_BR
dc.publisherSpringer International Publishing AG.pt_BR
dc.relation.ispartofseriesThe Minerals, Metals & Materials Seriespt_BR
dc.rightsclosedAccesspt_BR
dc.subjecthydrogels
dc.subjectpolymers
dc.subjectantibiotics
dc.subjectdrugs
dc.subjectwounds
dc.subjectneomycin
dc.subjectpvp
dc.subjectirradiation
dc.titleSynthesis of polymeric hydrogel loaded with antibiotic drug for wound healing applicationspt_BR
dc.title.livroCharacterization of Minerals, Metals, and Materials. TMSpt_BR
dc.typeCapítulo de livropt_BR
dspace.entity.typePublication
ipen.autorDUCLERC FERNANDES PARRA
ipen.autorADEMAR BENEVOLO LUGAO
ipen.autorVINICIUS JUVINO DOS SANTOS
ipen.autorANGELICA TAMIÃO ZAFALON
ipen.codigoautor562
ipen.codigoautor339
ipen.codigoautor14044
ipen.codigoautor6419
ipen.contributor.ipenauthorDUCLERC FERNANDES PARRA
ipen.contributor.ipenauthorADEMAR BENEVOLO LUGAO
ipen.contributor.ipenauthorVINICIUS JUVINO DOS SANTOS
ipen.contributor.ipenauthorANGELICA TAMIÃO ZAFALON
ipen.date.recebimento18-04pt_BR
ipen.identifier.ipendoc24657pt_BR
ipen.type.genreCapítulo
relation.isAuthorOfPublication67996d86-0a59-4ba2-8d38-facaa14e26c3
relation.isAuthorOfPublication99ac24c5-2ae1-465a-a6f2-40b4d9af6af7
relation.isAuthorOfPublicatione7446613-4b8b-42e0-a53b-077674c2c830
relation.isAuthorOfPublication49d823d7-3167-4065-8db0-9ed6915062cc
relation.isAuthorOfPublication.latestForDiscovery49d823d7-3167-4065-8db0-9ed6915062cc
sigepi.autor.atividadeZAFALON, ANGELICA T.:6419:740:Spt_BR
sigepi.autor.atividadeSANTOS, VINICIUS J. DOS:14044:750:Npt_BR
sigepi.autor.atividadeLUGAO, ADEMAR B.:339:740:Npt_BR
sigepi.autor.atividadePARRA, DUCLERC F.:562:740:Npt_BR

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