Mitochondrial effects of low-level light
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Laser Therapies: Types, Uses and Safety
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Resumo
Since the discovery of light amplified by stimulated emission of
radiation – Lasers – in 1967, the effects of light on the improvement of
tissue healing, promoting pain relief, decreasing inflammation and
swelling, as well as preventing further tissue damage, have been known
and constantly studied. Due to these useful properties for health, the
interest of researchers for photobiomodulation has been growing,
especially with the advent of light-emitting diodes and other light sources
with various wavelengths. There are many known effects of light at the
molecular level, and most of them occur in the mitochondria (especially by
the interaction of light with cytochrome-C oxidase), such as increased ATP
production, differential gene expression due to the induction of
transcription factors, and altered oxidative status due to the modulation of
oxidative stress. This chapter provides up-to-date information regarding
those molecular and cellular mechanisms of low-level light according to
wavelength, light dose, and other parameters, as well as some of its
consequences in the cellular and tissue levels. The concept of the Arndt-Schulz curve, regarding the biphasic dose response to low-level light, is
also explained.
Como referenciar
FREITAS, LUCAS F. de. Mitochondrial effects of low-level light. In: RAI, VIKRANT (ed.). Laser Therapies: Types, Uses and Safety. New York, NY, USA: Nova Science Publishers, 2020. , cap. 3. p. 95-118. Disponível em: http://repositorio.ipen.br/handle/123456789/32346. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.