Synergizing immune balance

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dc.contributor.authorTEIXEIRA, BRUNA H.
dc.contributor.authorGONCALVES, KARINA de O.
dc.contributor.authorVIEIRA, DANIEL P.
dc.contributor.authorCOURROL, LILIA C.
dc.coverageInternacional
dc.date.accessioned2024-06-11T19:01:47Z
dc.date.available2024-06-11T19:01:47Z
dc.date.issued2024
dc.description.abstractThe multifaceted health benefits of curcumin (Curcuma longa), attributed to its antioxidant, antitumor, and anti-inflammatory activities, have drawn significant scientific attention. Curcumin shows promise as a potential modulator of macrophage polarization, offering a natural strategy for managing inflammation and promoting tissue repair. However, a limiting factor for this beneficial molecule is its limited bioavailability due to its low solubility in water. This study aimed to quantify the effect of curcumin gold nanoparticle (CurAuNP)-mediated ultrasound irradiation on THP-1-derived macrophages as potential therapeutic targets. The photoreduction method was applied to synthesize the gold nanoparticles with curcumin as a ligand (CurAu). The effect of adding polyethylene glycol in the synthesis process was studied (CurAuPEG). CurAuNP characterization included UV/Vis, Zeta potential, transmission electron microscopy, and FTIR. The amount of singlet oxygen released by curcumin and CurAuNPs was quantified by observing 1.3-diphenylisobenzofuran quenching upon ultrasound irradiation (1 MHz and 1 W/cm2). The results indicated that ultrasound therapy for 4 min with CurAuNPs significantly enhanced singlet oxygen generation and reduced macrophage viability compared to curcumin alone. The increased sonoluminescence and curcumin delivery facilitated by CurAuNPs led to greater curcumin activation. Consequently, CurAuNPs could offer promising therapeutic options for modulating macrophage polarization in pro-inflammatory and anti-inflammatory stages.
dc.description.sponsorshipInstituto Nacional de Ciência e Tecnologia de Fluidos Complexos (INCT-FCx)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDINCT-FCx: 2014/50983-3
dc.description.sponsorshipIDFAPESP: 22/14030-8
dc.format.extent70-85
dc.identifier.citationTEIXEIRA, BRUNA H.; GONCALVES, KARINA de O.; VIEIRA, DANIEL P.; COURROL, LILIA C. Synergizing immune balance: curcumin gold nanoparticles and ultrasound irradiation for macrophage down-regulation. <b>AppliedChem</b>, v. 4, n. 1, p. 70-85, 2024. DOI: <a href="https://dx.doi.org/10.3390/appliedchem4010006">10.3390/appliedchem4010006</a>. Disponível em: https://repositorio.ipen.br/handle/123456789/48068.
dc.identifier.doi10.3390/appliedchem4010006
dc.identifier.fasciculo1
dc.identifier.issn2673-9623
dc.identifier.orcidhttps://orcid.org/0000-0002-0007-534X
dc.identifier.percentilfiSem Percentil F.I.
dc.identifier.percentilfiCiteScoreSem Percentil CiteScore
dc.identifier.urihttps://repositorio.ipen.br/handle/123456789/48068
dc.identifier.vol4
dc.relation.ispartofAppliedChem
dc.rightsopenAccess
dc.subjectcurcumin
dc.subjectgold
dc.subjectnanoparticles
dc.subjectultrasonic waves
dc.subjectultrasonography
dc.subjectinflammation
dc.titleSynergizing immune balance
dc.typeArtigo de periódico
dspace.entity.typePublication
ipen.autorKARINA DE OLIVEIRA GONÇALVES
ipen.autorDANIEL PEREZ VIEIRA
ipen.codigoautor8710
ipen.codigoautor3158
ipen.contributor.ipenauthorKARINA DE OLIVEIRA GONÇALVES
ipen.contributor.ipenauthorDANIEL PEREZ VIEIRA
ipen.identifier.fiSem F.I.
ipen.identifier.fiCiteScoreSem CiteScore
ipen.identifier.ipendoc30388
ipen.subtitulocurcumin gold nanoparticles and ultrasound irradiation for macrophage down-regulation
ipen.type.genreArtigo
relation.isAuthorOfPublicationc6eabf94-3a6b-45d3-ae67-5f67fe868b53
relation.isAuthorOfPublicationc2352608-be9c-4a73-be8c-571f10bb53d2
relation.isAuthorOfPublication.latestForDiscoveryc6eabf94-3a6b-45d3-ae67-5f67fe868b53
sigepi.autor.atividadeKARINA DE OLIVEIRA GONÇALVES:8710:750:N
sigepi.autor.atividadeDANIEL PEREZ VIEIRA:3158:810:N
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