Label-free Infrared spectroscopic imaging for characterization of necrotic tissue areas on cutaneous squamous cell carcinoma
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2019
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SPIE PHOTONICS WEST; SPIE BIOS
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In this study, FTIR spectroscopy was used to evaluate the overall biochemical status of necrotic tissue areas of cutaneous
squamous cell carcinoma chemically-induced on mice. FTIR hyperspectral image collected from specimen showed high
correlation with the photomicrograph obtained by light microscopy, in which we were able to identify clusters associated
to keratin, necrosis and regions with no tissue. Alterations in the protein content were documented in the necrotic tissue
areas, indicating changes on protein conformation.
Como referenciar
LIMA, CASSIO A.; CORREA, LUCIANA; BYRNE, HUGH J.; ZEZELL, DENISE M. Label-free Infrared spectroscopic imaging for characterization of necrotic tissue areas on cutaneous squamous cell carcinoma. In: MAHADEVAN-JANSEN, ANITA (ed.); GRUNDFEST, WARREN S. (ed.). In: SPIE PHOTONICS WEST; SPIE BIOS, February 2-7, 2019, San Francisco, USA. Proceedings... Washington, USA: SPIE, 2019. p. 1086812-1 - 1086812-6. (Proceedings SPIE 10868, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVII). DOI: 10.1117/12.2510711. Disponível em: http://repositorio.ipen.br/handle/123456789/30150. Acesso em: 27 Mar 2026.
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