Essential elements as biomarkers of metastatic renal cell carcinoma
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Medical & Clinical Research
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Renal cell carcinoma (RCC) represents 3% of human malignant tumors and approximately 90% of malignant renal neoplasms.
Despite great therapeutic advances in the last decade, metastatic RCC (mRCC) is still considered an incurable disease. In
this study, we examined the potential of essential elements as biomarkers of mRCC using an orthotropic metastatic mouse
model. Frozen lung and plasma samples from healthy and mRCC-induced mice were lyophilized, digested, and analyzed using
inductively coupled plasma mass spectrometry. In metastatic lungs, a significant increase in Ca concentration (268%) was
observed, whereas a significant decrease in Cu (23.2%), Fe (17.4%), Mn (38.8%), and Na (11.7%) was observed. The plasma
of mRCC-induced mice showed decreased concentrations of Mn (53%), Na (19.7%) and Zn (49,50%) and increased levels of
Ca (53%), Cu (39.5%), Our findings revealed marked differences in the concentrations of essential elements in the lung and
plasma of the metastatic mouse model. The circulating levels of Ca, Cu, Mn, Na, and Zn could be utilized as diagnostic and
therapeutic response biomarkers.
Como referenciar
BELLINI, MARIA H.; SOUZA, ALEXANDRE L. de; SILVA, FABIO F. da; GUILHEN, SABINE N.; FERREIRA, RAFAEL V. de P.; OLIVEIRA, JOAO E. de; MARUMO, JULIO T. Essential elements as biomarkers of metastatic renal cell carcinoma. Medical & Clinical Research, v. 5, n. 7, p. 143-146, 2020. DOI: 10.33140/MCR.05.07.04. Disponível em: http://repositorio.ipen.br/handle/123456789/31416. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.