Electronic stopping of protons in dna from first principles

Abstract

Introduction: Ions energy-loss in targets, such as DNA, is crucial for understanding radiation effects in cancer therapy [1–3]. The quality of proton radiotherapy planning is directly influenced by accurate information on electronic stopping cross-section (SCS), emphasizing the ongoing importance of its accuracy [4]. This work aims to determine the proton’s electronic stopping in DNA using the time-dependent density functional theory (TDDFT) [5–8], combined with the Penn method [9,10], and compare it with the database [11–12]. Furthermore, the dose profile and proton range will be calculated using those electronic stopping TDDFT-Penn results on the MCNP 6.2 code [13].