Stability in production and transport of 177Lu labeled PSMA

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dc.contributor.authorVILLAS BOAS, C.A.W.pt_BR
dc.contributor.authorDIAS, L.A.P.pt_BR
dc.contributor.authorMATSUDA, M.M.N.pt_BR
dc.contributor.authorARAUJO, E.B.pt_BR
dc.coverageNacionalpt_BR
dc.date.accessioned2021-08-02T16:08:07Z
dc.date.available2021-08-02T16:08:07Z
dc.date.issued2021pt_BR
dc.description.abstractIn Brazil, prostate cancer is a common disease among men. The radionuclide therapy with PSMA analogs, labeled with beta and alpha emitters, has brought new perspectives for patients with multi metastatic resistant prostate cancer. The commercialization of radiopharmaceutical becomes a challenge to transport and ensure the quality of the product, especially in terms of radiochemical stability of therapeutic radiopharmaceuticals. The effect of radiolysis on therapeutic doses of radiopharmaceuticals can be avoided or mitigated by diluting the final dose and reducing storage and transportation temperature. This study evaluated the effect of radiolysis on the different radioactive concentration in the industrial batches of 177Lu-PSMA-617 and in the fractionated doses, considering long time transportation. The radiopharmaceutical 177Lu-PSMA-617 was produced in batches reaching 37 GBq, and stability studies were performed in controlled conditions. The results showed that a combination of factors, including reaction buffer, the radioactive concentration of final product, and freezing storage contributed to the stability of the radiopharmaceutical for 48 hours, enabling transport of 177Lu-PSMA-617 to distant regions of the country.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipIDFAPESP: 18/12965-4pt_BR
dc.format.extent1-12pt_BR
dc.identifier.citationVILLAS BOAS, C.A.W.; DIAS, L.A.P.; MATSUDA, M.M.N.; ARAUJO, E.B. Stability in production and transport of 177Lu labeled PSMA. <b>Brazilian Journal of Radiation Sciences</b>, v. 9, n. 1, p. 1-12, 2021. DOI: <a href="https://dx.doi.org/10.15392/bjrs.v9i1.1619">10.15392/bjrs.v9i1.1619</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/32077.
dc.identifier.doi10.15392/bjrs.v9i1.1619pt_BR
dc.identifier.fasciculo1pt_BR
dc.identifier.issn2319-0612pt_BR
dc.identifier.orcid0000-0003-4455-3486pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0456-5589
dc.identifier.orcidhttps://orcid.org/0000-0003-4455-3486
dc.identifier.percentilfiSem Percentilpt_BR
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/32077
dc.identifier.vol9pt_BR
dc.relation.ispartofBrazilian Journal of Radiation Sciencespt_BR
dc.rightsopenAccesspt_BR
dc.subjectneoplasms
dc.subjectprostate
dc.subjectlutetium 177
dc.subjectantigens
dc.subjectradiopharmaceuticals
dc.subjectradiolysis
dc.subjectstability
dc.titleStability in production and transport of 177Lu labeled PSMApt_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorELAINE BORTOLETI DE ARAUJO
ipen.autorMARGARETH MIE NAKAMURA MATSUDA
ipen.autorLUIS ALBERTO PEREIRA DIAS
ipen.autorCRISTIAN ANTONIO WIECZOREK VILLAS BOAS
ipen.codigoautor664
ipen.codigoautor841
ipen.codigoautor796
ipen.codigoautor14503
ipen.contributor.ipenauthorELAINE BORTOLETI DE ARAUJO
ipen.contributor.ipenauthorMARGARETH MIE NAKAMURA MATSUDA
ipen.contributor.ipenauthorLUIS ALBERTO PEREIRA DIAS
ipen.contributor.ipenauthorCRISTIAN ANTONIO WIECZOREK VILLAS BOAS
ipen.date.recebimento21-08
ipen.identifier.fiSem F.I.pt_BR
ipen.identifier.ipendoc27848pt_BR
ipen.type.genreArtigo
relation.isAuthorOfPublicationca74886d-6974-47a8-9308-c4cc39bb6e35
relation.isAuthorOfPublicationfa01cabc-d76d-45ee-bb21-4994c14ba167
relation.isAuthorOfPublication50b3adab-a651-4225-a05c-ec1b1e37e921
relation.isAuthorOfPublicationdf5938f0-d4f2-4973-88b2-c61febb4d3bf
relation.isAuthorOfPublication.latestForDiscoverydf5938f0-d4f2-4973-88b2-c61febb4d3bf
sigepi.autor.atividadeARAUJO, E.B.:664:110:Npt_BR
sigepi.autor.atividadeMATSUDA, M.M.N.:841:110:Npt_BR
sigepi.autor.atividadeDIAS, L.A.P.:796:110:Npt_BR
sigepi.autor.atividadeVILLAS BOAS, C.A.W.:14503:110:Spt_BR
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