Does photobiomodulation affects CK10 and CK14 in oral mucositis radioinduced repair?
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International Journal of Molecular Sciences
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The mechanisms of action of photobiomodulation (PBM) in oral mucositis (OM) are not
completely elucidated. To enlighten the role of PBM in the evolution of epithelial maturity in OM
ulcers, the present study evaluated the effect of PBM with red ( ) wavelength of 660 nanometers (nm)
and infrared of 780 nm in radio-induced OM wounds on the tongue of rats, eight and twenty days
after irradiation with single dose of 20 Gy. The percentage area corresponding to positive staining
for cytokeratin 10 (CK10) and 14 (CK14) proteins was evaluated in the epithelial area of the lesions,
using an immunohistochemical technique (IHC), 8 and 20 days after the induction of lesions, and
compared with an untreated control group. CK10 was significantly more expressed in the group
treated with 660 nm PBM. CK14 did not show quantitative differences between the groups evaluated.
However, whereas in the groups treated with PBM, CK14 was already restricted to the basal layer
of the epithelium, as expected in healthy epithelia, in control group it was also expressed in upper
layers of the epithelium. In this work, PBM was able to improve epithelial maturity of the repaired
OM wound, especially in the 660 nm group.
Como referenciar
SARDO, ARIANE V.N.; ANDRADE, MAIRA F.; FIGUEIREDO, ANAELIZA; ROSIN, FLAVIA C.P.; CORREA, LUCIANA; ZEZELL, DENISE M. Does photobiomodulation affects CK10 and CK14 in oral mucositis radioinduced repair?. International Journal of Molecular Sciences, v. 23, n. 24, p. 1-9, 2022. DOI: 10.3390/ijms232415611. Disponível em: http://repositorio.ipen.br/handle/123456789/33868. Acesso em: 24 Mar 2026.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.