Polyol-chitosan dendrimers for leishmaniosis treatment
Carregando...
Data
Data de publicação
2003
Autores IPEN
Orientador
Título da Revista
ISSN da Revista
Título do Volume
É parte de
É parte de
É parte de
É parte de
ENCONTRO DA SOCIEDADE BRASILEIRA DE PESQUISA EM MATERIAIS, 2.; SYMPOSIUM B: ADVANCES IN THE DEVELOPMENT OF BIOMATERIALS 2.
Exportar
Resumo
Macromolecular dendrimers have gained an attention in the molecular biology due to their
endoreceptor and exoreceptor properties. In this sense, biologically active dendrimers have been
successfully used for the development of drug and gene delivery systems, vaccines, anti-cancer,
antiviral agents as well as protein mimetics. In this work, we report on the preliminary in vivo
evaluation of the borated polyol-chitosan dendrimers (PG-Ch/B) with high potential for the
treatment of the visceral and cutaneous leishmaniosis by the boron neutron capture therapy
(BNCT). The PG-Ch/B complexes exhibited high swelling degree without dissolution relatively to
the chitosan films or their physical mixtures with boric acid and glycerin. The phagocytosis of the
PG-Ch/B by homogeneous mouse peritoneal macrophages was evaluated by the phase-contrast
microscopy. The results indicated that the interfacial free energy may be important one for the
attachment of the dendrimer to the phagocytic cell and that the optimal hydrophobicity of the
polyol surface may be responsible for the susceptibility to phagocytosis.
Como referenciar
CAMILLO, M.A.P.; HIGA, O.Z.; ABRAHAM, G.A.; QUEIROZ, A.A.A.; SAN ROMAN, J. Polyol-chitosan dendrimers for leishmaniosis treatment. In: ENCONTRO DA SOCIEDADE BRASILEIRA DE PESQUISA EM MATERIAIS, 2.; SYMPOSIUM B: ADVANCES IN THE DEVELOPMENT OF BIOMATERIALS 2., 26-29 out, 2003, Rio de Janeiro, RJ. Resumos... p. 90. Disponível em: http://repositorio.ipen.br/handle/123456789/21897. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.