In vitro cytotoxicity test and surface characterization of CoCrW alloy in artificial saliva solution for dental applications
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Brazilian Dental Journal
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In order to evaluate its application as a dental prosthesis material, a CoCrW alloy was
subjected to in vitro cytotoxicity test, surface characterization and electrochemical
studies performed in artificial saliva and 0.15 mol.L-1 NaCl medium. The used techniques
were: anodic polarization curves, chronoamperometric measurements, electrochemical
impedance spectroscopy (EIS), scanning electron microscopy (SEM), energy dispersive X-ray
spectroscopy (EDS) analysis and X-ray photoelectron spectroscopy (XPS). Cytotoxicity
test was also performed. The electrochemical behavior of CoCrW alloy was compared
in both studied media, from corrosion potential (Ecorr) to a 600 mV anodic overvoltage.
From the electrochemical measurements it was observed that the CoCrW alloy in both
media presents only generalized corrosion. SEM and EDS analysis showed that the alloy
presents carbide niobium and silicon and manganese oxides as nonmetallic inclusions.
XPS results indicated that cobalt does not significantly contribute to the passivating film
formation. Cytotoxicity test showed no cytotoxic character of CoCrW alloy. These results
suggest that the CoCrW alloy can be used as biomaterial to be applied as prosthesis in
dental implants.
Como referenciar
SOUZA, KLESTER S.; JAIMES, RUTH F.V.V.; ROGERO, SIZUE O.; NASCENTE, PEDRO A. de P.; AGOSTINHO, SILVIA M.L. In vitro cytotoxicity test and surface characterization of CoCrW alloy in artificial saliva solution for dental applications. Brazilian Dental Journal, v. 27, n. 1, p. 181-186, 2016. DOI: 10.1590/0103-6440201300513. Disponível em: http://repositorio.ipen.br/handle/123456789/26514. Acesso em: 30 Jun 2026.
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