Ecotoxicological assessment of metformin as an antidiabetic water residue treated by electron beam accelerator irradiation

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dc.contributor.authorTOMINAGA, FLAVIO K.
dc.contributor.authorJESUS, JULIANA M.S. de
dc.contributor.authorKLANOVICZ, NATALIA
dc.contributor.authorREDIGOLO, MARCELO M.
dc.contributor.authorSILVA, THALITA T.
dc.contributor.authorLEBRE, DANIEL T.
dc.contributor.authorTEIXEIRA, ANTONIO C.S.C.
dc.contributor.authorLEO, PATRICIA
dc.contributor.authorBORRELY, SUELI I.
dc.coverageInternacional
dc.date.accessioned2024-04-05T13:25:28Z
dc.date.available2024-04-05T13:25:28Z
dc.date.issued2024
dc.description.abstractMetformin (MET), an antidiabetic compound, has received increasing attention, as it cannot be effectively removed during conventional wastewater treatment processes and may act as an endocrine disruptor. Electron beam irradiation (EBI) is an eco-friendly process able to degrade and neutralize biohazardous pollution almost instantly. In this context, this study applied EBI to MET degradation and detoxification in aqueous solutions. A 98% MET degradation rate and TOC removal of 19.04 ± 1.20% at a 1.0 kGy EBI dose was obtained, with up to 65% mineralization reached at 5.0 kGy. Toxicity assays were performed with Vibrio fischeri, Saccharomyces cerevisiae, and Daphnia similis, and the findings indicate that generated byproducts were only more toxic to D. similis. This reveals the need to assess organisms belonging to different trophic levels. A cytotoxic assessment employing Allium cepa roots demonstrated no toxic effects concerning untreated and irradiated samples.
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIDCNPq: 141947/2018-7
dc.identifier.citationTOMINAGA, FLAVIO K.; JESUS, JULIANA M.S. de; KLANOVICZ, NATALIA; REDIGOLO, MARCELO M.; SILVA, THALITA T.; LEBRE, DANIEL T.; TEIXEIRA, ANTONIO C.S.C.; LEO, PATRICIA; BORRELY, SUELI I. Ecotoxicological assessment of metformin as an antidiabetic water residue treated by electron beam accelerator irradiation. <b>Discover Water</b>, v. 4, n. 1, 2024. DOI: <a href="https://dx.doi.org/10.1007/s43832-023-00053-x">10.1007/s43832-023-00053-x</a>. Disponível em: https://repositorio.ipen.br/handle/123456789/48017.
dc.identifier.doi10.1007/s43832-023-00053-x
dc.identifier.fasciculo1
dc.identifier.issn2730-647X
dc.identifier.orcidhttps://orcid.org/0000-0002-9692-5539
dc.identifier.percentilfiSem Percentil F.I.
dc.identifier.percentilfiCiteScoreSem Percentil CiteScore
dc.identifier.urihttps://repositorio.ipen.br/handle/123456789/48017
dc.identifier.vol4
dc.relation.ispartofDiscover Water
dc.rightsopenAccess
dc.subjectelectron beams
dc.subjectirradiation
dc.subjectirradiation procedures
dc.subjectdrugs
dc.subjectremoval
dc.subjectwater treatment
dc.subjectchemical composition
dc.subjectresidues
dc.subjecttoxicity
dc.subjectdecontamination
dc.titleEcotoxicological assessment of metformin as an antidiabetic water residue treated by electron beam accelerator irradiation
dc.typeArtigo de periódico
dspace.entity.typePublication
ipen.autorFLAVIO KIYOSHI TOMINAGA
ipen.autorMARCELO MIYADA REDÍGOLO
ipen.autorTHALITA TIEKO SILVA
ipen.autorDANIEL TEMPONI LEBRE
ipen.autorSUELI IVONE BORRELY
ipen.codigoautor12754
ipen.codigoautor5976
ipen.codigoautor15126
ipen.codigoautor2053
ipen.codigoautor150
ipen.contributor.ipenauthorFLAVIO KIYOSHI TOMINAGA
ipen.contributor.ipenauthorMARCELO MIYADA REDÍGOLO
ipen.contributor.ipenauthorTHALITA TIEKO SILVA
ipen.contributor.ipenauthorDANIEL TEMPONI LEBRE
ipen.contributor.ipenauthorSUELI IVONE BORRELY
ipen.identifier.fiSem F.I.
ipen.identifier.fiCiteScoreSem CiteScore
ipen.identifier.ipendoc30206
ipen.type.genreArtigo
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relation.isAuthorOfPublication3cae4a76-5492-456b-9c40-409024c0ea88
relation.isAuthorOfPublicationb1305c93-be39-477e-97ae-bd94c730015d
relation.isAuthorOfPublication76171e20-c8ac-475f-9006-27402113c92f
relation.isAuthorOfPublication.latestForDiscoveryaa4a15b8-4ad7-4bb6-a280-c0de5cf947d6
sigepi.autor.atividadeFLAVIO KIYOSHI TOMINAGA:12754:220:S
sigepi.autor.atividadeMARCELO MIYADA REDÍGOLO:5976:730:N
sigepi.autor.atividadeTHALITA TIEKO SILVA:15126:220:N
sigepi.autor.atividadeDANIEL TEMPONI LEBRE:2053:520:N
sigepi.autor.atividadeSUELI IVONE BORRELY:150:220:N
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