Influence of gama radiation onto polymeric matrix with papain
Carregando...
Data
Data de publicação
2008
Orientador
Título da Revista
ISSN da Revista
Título do Volume
É parte de
É parte de
É parte de
É parte de
INTERNATIONAL SYMPOSIUM ON IONIZING RADIATION AND POLYMERS, 8th
Exportar
Resumo
Papain is a proteolytic enzyme that has been widely used as debridement agent for scars and wound
healing treatment. However, papain presents low stability, which limits its use to extemporaneous or
short shelf-life formulations. The purpose of this study was to entrap papain into a polymeric matrix in
order to obtain a drug delivery system that could be used as medical device. Since these systems must
be sterile, gamma radiation is an interesting option and presents advantages in relation to conventional
agents: no radioactive residues are formed; the product can be sterilized inside the final packaging and
has an excellent reliability. The normative reference for the establishment of the sterilizing dose
determines 25 kGy as the inactivation dose for viable microorganisms. A silicone dispersion was
selected to prepare membranes containing 2% (w/w) papain. Irradiated and non-irradiated membranes
were simultaneously assessed in order to verify whether gamma radiation interferes with the drugreleasing profile. Results showed that irradiation does not affect significantly papain release and its
activity. Therefore papain shows radioresistance in the irradiation conditions applied. In conclusion,
gamma radiation can be easily used as sterilizing agent without affecting the papain release profile and
its activity onto the biocompatible device is studied.
Como referenciar
ZULLI, GISLAINE; LOPES, PATRICIA S.; VELASCO, MARIA V.R.; ALCANTARA, MARA T.S.; ROGERO, SIZUE O.; LUGAO, ADEMAR B.; MATHOR, MONICA B. Influence of gama radiation onto polymeric matrix with papain. In: INTERNATIONAL SYMPOSIUM ON IONIZING RADIATION AND POLYMERS, 8th, 12-17 de outubro, 2008, Angra dos Resis, RJ. Abstract... p. 63. DOI: 10.1016/j.radphyschem.2009.08.025. Disponível em: http://repositorio.ipen.br/handle/123456789/22306. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.