Gamma Knife radiosurgery for vestibular schwannomas

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dc.contributor.authorSARAIVA, CRYSTIAN W.C.pt_BR
dc.contributor.authorCARDOSO, SIMONE C.pt_BR
dc.contributor.authorGROPPO, DANIELA P.pt_BR
dc.contributor.authorSALLES, ANTONIO A.F. dept_BR
dc.contributor.authorAVILA, LUIZ F. dept_BR
dc.contributor.authorROSA, LUIZ A.R. dapt_BR
dc.coverageInternacionalpt_BR
dc.date.accessioned2020-04-06T14:57:41Z
dc.date.available2020-04-06T14:57:41Z
dc.date.issued2020pt_BR
dc.description.abstractIntroduction This study explores the possibility of a relationship between the sphericity degree of a target volume with the dose distribution. This relationship is evaluated based on the ratio isodose volume / target volume (IV/TV) and the metrics coverage, i.e., selectivity, gradient index, conformity index and mean dose when planning radiosurgery for vestibular schwannoma. Methods Sphericity degree (φ) was calculated for each target volume (TV) of 64 patients who underwent stereotactic radiosurgery (SRS) for vestibular schwannoma. The calculation of this parameter was developed using the theoretical definition for operational sphericity φ = VP/ VCS. The values found are evaluated considering the following metrics:—Coverage (C), selectivity (S), gradient index (GI), Paddick conformity index (CIPaddick) and dose distribution (IV/TV). The planning was also carried out considering a spherical target volume defined in a spherical phantom. The spherical volume is the same as the target used in the treatment plan. The planning of the spherical target was considered as a reference plan to evaluate the dose distribution inside and outside the volume. Results It was possible to observe that the majority of target volumes has (ϕ) around 0,66–0,77, corresponding to 54,7% of the total. Considering the mean values for metrics, the results are: C = 0,98, S = 0,78, GI = 3,11 and CI = 0,81. The dose distribution was equivalent for treatment plans and reference plans. Quantitative analysis for IV/TV shows that these values are higher than 30% for treatment plans where shot density is large. Conclusion This study demonstrates that de sphericity degree (φ) can be related to the dose distribution (IV/TV). Therefore the sphericity degree is a good parameter to evaluate the dose distribution of a plan for vestibular schwannoma treatment, considering the reference plan as being a spherical target using a leksell gamma knife® perfexion (LGKP). This study shows that the sphericity degree offers important information of the dose distribution outside and inside the target volume. This is not evaluated by the other parameters already implemented as metric to analyzing the GKP plans.pt_BR
dc.format.extent1-18pt_BR
dc.identifier.citationSARAIVA, CRYSTIAN W.C.; CARDOSO, SIMONE C.; GROPPO, DANIELA P.; SALLES, ANTONIO A.F. de; AVILA, LUIZ F. de; ROSA, LUIZ A.R. da. Gamma Knife radiosurgery for vestibular schwannomas: evaluation of planning using the sphericity degree of the target volume. <b>PLoS One</b>, v. 15, n. 1, p. 1-18, 2020. DOI: <a href="https://dx.doi.org/10.1371/journal.pone.0225638">10.1371/journal.pone.0225638</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/31086.
dc.identifier.doi10.1371/journal.pone.0225638pt_BR
dc.identifier.fasciculo1pt_BR
dc.identifier.issn1932-6203pt_BR
dc.identifier.percentilfi65.07pt_BR
dc.identifier.percentilfiCiteScore92.00
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/31086
dc.identifier.vol15pt_BR
dc.relation.ispartofPLoS Onept_BR
dc.rightsopenAccesspt_BR
dc.subjectneoplasms
dc.subjectradiotherapy
dc.subjectsurgery
dc.subjectgamma radiation
dc.subjectvestibular apparatus
dc.subjecttherapy
dc.subjectradiation doses
dc.subjectisodose curves
dc.titleGamma Knife radiosurgery for vestibular schwannomaspt_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorDANIELA PIAI GROPPO
ipen.codigoautor9729
ipen.contributor.ipenauthorDANIELA PIAI GROPPO
ipen.date.recebimento20-04
ipen.identifier.fi3.240pt_BR
ipen.identifier.fiCiteScore5.3
ipen.identifier.ipendoc26872pt_BR
ipen.identifier.iwosWoSpt_BR
ipen.range.fi3.000 - 4.499
ipen.range.percentilfi50.00 - 74.99
ipen.subtituloevaluation of planning using the sphericity degree of the target volumept_BR
ipen.type.genreArtigo
relation.isAuthorOfPublicationa092c2d5-0541-4e14-a0f5-14c414026dbe
relation.isAuthorOfPublication.latestForDiscoverya092c2d5-0541-4e14-a0f5-14c414026dbe
sigepi.autor.atividadeGROPPO, DANIELA P.:9729:330:Npt_BR
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