Bio-absorption procedure with gamma irradiated suture for brachytherapy strand application
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2007
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INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE; MEETING ON NUCLEAR APPLICATIONS, 8th/ MEETING ON REACTOR PHYSICS AND THERMAL HYDRAULICS, 15th
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Bio-absorbable sutures are largely used to hold and wind tissues together in good apposition until completing
the healing process, without needing future removal. There are some materials commonly used for these
sutures, such as polyglycolide, polylactide, poly(ecaprolactone), mucosa or beef intestines. Some of these
materials have marked or moderate tissue reaction, like mucosa or beef intestines, and could not be used for
some delicate applications, like braiding brachytherapy seed strands. The best option for this application is
Vicryl sutures, trade mark of Johnson&Johnson company. Vicryl has a bio-absortion time still a little long, for
brachytherapy application, but it could be accelerated imparting a dose of ionizing radiation in the strand,
before using it. In this work, it is shown the procedure where small hanks of Vicryl wires (fifteen centimeters
unrolled), surgical diameter number 7-0 (~50 mm), were inserted into rats underskin and removed for
mechanical and histological evaluation after 15, 30 and 60 days. Wire samples were irradiated with gamma
doses of 10, 25 and 50kGy, besides those non-irradiated. Preliminary mechanical evaluation was carried out
in a EMIC DL 2000 machine, using NBR 13904 standard normative test. Fifty grays caused great degradation
on wires, preventing any traction evaluation. Small doses are promising for accelerating bio-absortion and the
samples mechanical tests results will be the scope of a future work.
Como referenciar
LEME, EDNILSE; SILVA, PATRICIA C.P.; MORIGUCHI, PATRICIA; RIBEIRO, SUZANA P.; ROSTELATO, MARIA E.C.M.; MONZOLI, JOSE E. Bio-absorption procedure with gamma irradiated suture for brachytherapy strand application. In: INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE; MEETING ON NUCLEAR APPLICATIONS, 8th/ MEETING ON REACTOR PHYSICS AND THERMAL HYDRAULICS, 15th, Sept. 30 - Oct. 5, 2007, Santos, SP. Proceedings... Disponível em: http://repositorio.ipen.br/handle/123456789/18092. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.