Essential elements as biomarkers of acute kidney injury and spontaneous reversion
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Biological Trace Element Research
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Acute kidney injury (AKI) is an important health
problem and can be caused by number of factors. The use of
aminoglycosides, such as gentamicin, is one of these factors.
Recently, an effort has been made to find biomarkers to guide
treatment protocols. Inductively coupled plasma optical emission
spectroscopy (ICP-OES) was used to estimate the contents
of Ca, Cu, Fe, K, Mg, Mn, Na, P, and Zn in serum and
urine of the healthy, AKI, and spontaneous recovery (SR)
groups of animals. The animal model of AKI and SR was
validated by measuring serum and urinary urea and creatinine.
The quantitative determination of the elements showed a decrease
in serum levels of Ca, and Fe in the AKI group (P<0.01
vs. healthy), with a return to normal levels in the SR group,
without a significant difference between the healthy and SR
groups. In the urine samples, there was a decrease in P and Na
levels in the AKI group (P<0.001 and P<0.01 vs. healthy), but
Ca levels were increased in this group compared with the
healthy and SR groups (P<0.01). These findings indicate that
mineral elements might be useful as biomarkers for AKI.
Como referenciar
SILVA, REGIANE M. da; KO, GUI MI; SILVA, RINALDO F.; VIEIRA, LUDMILA C.; PAULA, RAFAEL V. de; MARUMO, JULIO T.; IKEGAMI, AMANDA; BELLINI, MARIA H. Essential elements as biomarkers of acute kidney injury and spontaneous reversion. Biological Trace Element Research, v. 182, n. 2, p. 303-308, 2018. DOI: 10.1007/s12011-017-1091-2. Disponível em: http://repositorio.ipen.br/handle/123456789/27833. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.