Vascular endothelial growth factor as a biomarker for endostatin gene therapy
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Biomedicine and Pharmacotherapy
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Renal cell carcinoma (RCC) is characterized by high vascular endothelial growth factor (VEGF)
production and, consequently, excessive angiogenesis. Several strategies have been developed to target
angiogenesis as a method for treating metastatic RCC (mRCC). Endostatin (ES) is a C-terminal fragment of
collagen XVIII that has antiangiogenic activity. The aim of this study was to investigate the predictive
value of circulating VEGF-A in a murine model of mRCC after ES gene therapy. ES therapy did not affect
the levels of collagen XVIII/ES or ES in the tissue. The circulating level of ES was increased in the control
and ES-treated groups (normal vs. control, P < 0.05 and ES-treated vs. control, P < 0.001), and the
intratumoral vessels were significantly decreased (ES-treated vs. control, P < 0.05). ES therapy decreased
the VEGF mRNA levels. The tissue and circulating levels of VEGF in the control group were significantly
higher than normal (P < 0.01 and P < 0.05, respectively). Treatment with ES significantly reduced the
VEGF concentrations in both compartments (P < 0.001 for tissue and P < 0.05 for plasma). Our findings
indicate that in addition to the directly targeted tumor vessels, ES exerts its antitumor effect by downregulating VEGF gene expression in renal tumor cells. Additionally, our findings point to the predictive
value of VEGF for ES therapy.
Como referenciar
BRAGA, MARINA S.; TURAÇA, THIAGO L.; FOGUER, KAREN; CHAVES, KAREN C.B.; PESQUERO, JOÃO B.; CHAMMAS, ROGER; SCHOR, NESTOR; BELLINI, MARIA H. Vascular endothelial growth factor as a biomarker for endostatin gene therapy. Biomedicine and Pharmacotherapy, v. 67, n. 6, p. 511-515, 2013. DOI: 10.1016/j.biopha.2013.04.008. Disponível em: http://repositorio.ipen.br/handle/123456789/4065. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.