Pentoxifylline modifies three-dimensional collagen lattice model contraction and expression of collagen types I and III by human fibroblasts derived from post-burn hypertrophic scars and from normal skin
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Burns
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Fibroblasts are thought to be partially responsible for the persisting contractile forces that result in burn contractures. Using a monolayer cell culture and fibroblast populated collagen lattice (FPCL) three-dimensional model we subjected hypertrophic scar and non-cicatricial fibroblasts to the antifibrogenic agent pentoxifylline (PTF – 1 mg/mL) in order to reduce proliferation, collagen types I and III synthesis and model contraction. Fibroblasts were isolated from post-burn hypertrophic scars (HSHF) and non-scarred skin (NHF). Cells were grown in monolayers or incorporated into FPCL's and exposed to PTF. In monolayer, cell number proliferation was reduced (46.35% in HSHF group and 37.73% in NHF group, p < 0.0001). PTF selectively inhibited collagen III synthesis in the HSHF group while inhibition was more evident to type I collagen synthesis in the NHF group. PTF also reduced contraction in both (HSHF and NHF) FPCL.
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ISAAC, CESAR; MATHOR, MONICA B.; BARIANI, GIOVANI; PAGGIARO, ANDRE O.; HERSON, MARISA R.; SCHAINBERG, CLÁUDIA G.; CARRASCO, SOLANGE; TEODORO, WALCY R.; YOSHINARI, NATALINO H.; FERREIRA, MARCUS C. Pentoxifylline modifies three-dimensional collagen lattice model contraction and expression of collagen types I and III by human fibroblasts derived from post-burn hypertrophic scars and from normal skin. Burns, v. 35, n. 5, p. 701-706, 2009. DOI: 10.1016/j.burns.2008.11.017. Disponível em: http://repositorio.ipen.br/handle/123456789/4839. Acesso em: 31 Dec 2025.
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