Quantification of retinal capillary nonperfusion in diabetics using wide-field optical coherence tomography angiography
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RETINA, The Journal of Retinal and Vitreous Diseases
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Purpose: To combine advances in high-speed, wide-field optical coherence tomography
angiography (OCTA) with image processing methods for semiautomatic quantitative
analysis of capillary nonperfusion in patients with diabetic retinopathy (DR).
Methods: Sixty-eight diabetic patients (73 eyes), either without retinopathy or with
different degrees of retinopathy, were prospectively recruited for volumetric swept-source
OCTA imaging using 12 mm · 12 mm fields centered at the fovea. A custom, semiautomatic
software algorithm was used to quantify areas of capillary nonperfusion.
Results: The mean percentage of nonperfused area was 0.1% (95% confidence interval:
0.0–0.4) in the eyes without DR; 2.1% (95% confidence interval: 1.2–3.7) in the nonproliferative
DR eyes (mild, moderate, and severe), and 8.5% (95% confidence interval:
5.0–14.3) in the proliferative DR eyes. The percentage of nonperfused area increased in
a statistically significant manner from eyes without DR, to eyes with nonproliferative DR, to
eyes with proliferative DR.
Conclusion: Capillary nonperfusion area in the posterior retina increases with increasing
DR severity as measured by swept-source OCTA. Quantitative analysis of retinal nonperfusion
on wide-field OCTA may be useful for early detection and monitoring of disease in
patients with diabetes and DR.
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ALIBHAI, A.Y.; PRETTO, LUCAS R. de; MOULT, ERIC M.; OR, CHRIS; ARYA, MALVIKA; MCGOWAN, MITCHELL; CARRASCO-ZEVALLOS, OSCAR; LEE, BYUNGKUN; CHEN, SIYU; BAUMAL, CAROLINE R.; WITKIN, ANDRE J.; REICHEL, ELIAS; FREITAS, ANDERSON Z. de; DUKER, JAY S.; FUJIMOTO, JAMES G.; WAHEED, NADIA K. Quantification of retinal capillary nonperfusion in diabetics using wide-field optical coherence tomography angiography. RETINA, The Journal of Retinal and Vitreous Diseases, v. 40, n. 3, p. 412-420, 2020. DOI: 10.1097/IAE.0000000000002403. Disponível em: http://repositorio.ipen.br/handle/123456789/31114. Acesso em: 27 Mar 2026.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.