The role of probiotics in maintaining immune homeostasis

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dc.contributor.authorTHIPE, VELAPHI C.pt_BR
dc.contributor.authorMENTOR, SHIREENpt_BR
dc.contributor.authorLIMA, CAROLINE S.A.pt_BR
dc.contributor.authorFREITAS, LUCAS F.pt_BR
dc.contributor.authorFONSECA, ANA C.M.pt_BR
dc.contributor.authorNOGUEIRA, KAMILA M.pt_BR
dc.contributor.authorRODRIGUES, ADRIANA S.pt_BR
dc.contributor.authorBATISTA, JORGE G.S.pt_BR
dc.contributor.authorFERREIRA, ARYEL H.pt_BR
dc.contributor.authorLUGAO, ADEMAR B.pt_BR
dc.contributor.editorDWIVEDI, M.K.pt_BR
dc.contributor.editorAMARESAN, N.pt_BR
dc.contributor.editorSANKARANARAYANAN, A.pt_BR
dc.contributor.editorHELEN KEMP, E.pt_BR
dc.coverageInternacionalpt_BR
dc.date.accessioned2022-05-06T11:34:54Z
dc.date.available2022-05-06T11:34:54Z
dc.date.issued2022pt_BR
dc.description.abstractThe immune system is a complex architecture of a collective and coordinated network regulated by various pathways to thermodynamically maintain immune homeostasis. The gut microbiota plays a pivotal role that offers significant stimuli (i.e., gut-brain, gut-lung, and gut-liver axis) for both innate and adaptive immunity, mediating immune and metabolic homeostasis. An intricate correlation between changes in the gut microbiota (dysbiosis) and common diseases/disorders have been attributed to the invasion of pathogens, constant use of antibiotics, and hypercytokinemia—a hallmark of immune homeostasis imbalance. These factors contribute to the severity of inflammatory diseases such as cardiovascular diseases, neurological disorders, and of late the coronavirus disease, Covid-19. Probiotics (Lactobacillus spp. and Bifidobacterium spp.) have been considered as alternative and/or adjuvant therapeutic in restoring the balance of gut microbiota for maintaining immune homeostasis and integrity. The probiotics catalyze dietary fibers and proteins to generate short-chain fatty acids and tryptophan to promote antiinflammatory cytokines, reduce epithelium permeability, reinforcing immunity in the gut mucosa, and regulating the systemic immune response. Herein, we review our overarching understanding of current applications of probiotics in amelioration of gut microbiome, and the improvement of gut barrier function and maintaining immune homeostasis. We also highlight clinical trials on probiotics with reported results for the treatment of inflammatory diseases. Additionally, the looming global Covid-19 pandemic makes it prudent to highlight the role of probiotics in both the innate and adaptive human immune responses, especially amid the Covid-19 vaccination paradigm.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipIDFAPESP: 19/15154-0
dc.format.extent41-58pt_BR
dc.identifier.capitulo3pt_BR
dc.identifier.citationTHIPE, VELAPHI C.; MENTOR, SHIREEN; LIMA, CAROLINE S.A.; FREITAS, LUCAS F.; FONSECA, ANA C.M.; NOGUEIRA, KAMILA M.; RODRIGUES, ADRIANA S.; BATISTA, JORGE G.S.; FERREIRA, ARYEL H.; LUGAO, ADEMAR B. The role of probiotics in maintaining immune homeostasis. In: DWIVEDI, M.K. (ed.); AMARESAN, N. (ed.); SANKARANARAYANAN, A. (ed.); HELEN KEMP, E. (ed.). <b>Probiotics in The Prevention and Management of Human Diseases</b>. London, United Kingdom: Academic Press, 2022. , cap. 3. p. 41-58. (A Scientific Perspective). DOI: <a href="https://dx.doi.org/10.1016/B978-0-12-823733-5.00024-6">10.1016/B978-0-12-823733-5.00024-6</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/33042.
dc.identifier.doi10.1016/B978-0-12-823733-5.00024-6pt_BR
dc.identifier.orcid0000-0002-1737-3191pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1737-3191
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/33042
dc.localLondon, United Kingdompt_BR
dc.publisherAcademic Presspt_BR
dc.relation.ispartofseriesA Scientific Perspectivept_BR
dc.rightsopenAccesspt_BR
dc.subjectlactobacillus
dc.subjectfermentation
dc.subjecthomeostasis
dc.subjectimmunity
dc.subjectinflammation
dc.subjectintestines
dc.titleThe role of probiotics in maintaining immune homeostasispt_BR
dc.title.livroProbiotics in The Prevention and Management of Human Diseasespt_BR
dc.typeCapítulo de livropt_BR
dspace.entity.typePublication
ipen.autorCAROLINE SANTOS ALVES DE LIMA
ipen.autorKAMILA MOREIRA NOGUEIRA
ipen.autorJORGE GABRIEL DOS SANTOS BATISTA
ipen.autorARYEL HEITOR FERREIRA
ipen.autorADEMAR BENEVOLO LUGAO
ipen.autorADRIANA DE SOUZA RODRIGUES
ipen.autorLUCAS FREITAS DE FREITAS
ipen.autorVELAPHI CLEMENT THIPE
ipen.codigoautor14945
ipen.codigoautor12758
ipen.codigoautor10274
ipen.codigoautor12722
ipen.codigoautor339
ipen.codigoautor15153
ipen.codigoautor14818
ipen.codigoautor15459
ipen.contributor.ipenauthorCAROLINE SANTOS ALVES DE LIMA
ipen.contributor.ipenauthorKAMILA MOREIRA NOGUEIRA
ipen.contributor.ipenauthorJORGE GABRIEL DOS SANTOS BATISTA
ipen.contributor.ipenauthorARYEL HEITOR FERREIRA
ipen.contributor.ipenauthorADEMAR BENEVOLO LUGAO
ipen.contributor.ipenauthorADRIANA DE SOUZA RODRIGUES
ipen.contributor.ipenauthorLUCAS FREITAS DE FREITAS
ipen.contributor.ipenauthorVELAPHI CLEMENT THIPE
ipen.date.recebimento22-05
ipen.identifier.ipendoc28700pt_BR
ipen.identifier.ods3
ipen.type.genreCapítulo
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sigepi.autor.atividadeLUGAO, ADEMAR B.:339:740:Npt_BR
sigepi.autor.atividadeFERREIRA, ARYEL H.:12722:750:Npt_BR
sigepi.autor.atividadeBATISTA, JORGE G.S.:10274:750:Npt_BR
sigepi.autor.atividadeRODRIGUES, ADRIANA S.:15153:750:Npt_BR
sigepi.autor.atividadeNOGUEIRA, KAMILA M.:12758:750:Npt_BR
sigepi.autor.atividadeFREITAS, LUCAS F.:14818:750:Npt_BR
sigepi.autor.atividadeLIMA, CAROLINE S.A.:14945:750:Npt_BR
sigepi.autor.atividadeTHIPE, VELAPHI C.:15459:740:Spt_BR
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