Induction of micronuclei by 153Sm-EDTMP in peripheral blood lymphocytes in vitro

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dc.contributor.authorSUZUKI, M.F.pt_BR
dc.contributor.authorSILVA, M.A.pt_BR
dc.contributor.authorGUIMARAES, M.I.C.C.pt_BR
dc.contributor.authorOKAZAKI, K.pt_BR
dc.coverageInternacionalpt_BR
dc.date.accessioned2014-07-30T17:21:43Zpt_BR
dc.date.accessioned2014-07-30T18:57:31Z
dc.date.available2014-07-30T17:21:43Zpt_BR
dc.date.available2014-07-30T18:57:31Z
dc.date.issued2002pt_BR
dc.description.abstractThe purpose of this study was to evaluate the degree of cytological radiation damage to lymphocytes induced by beta particle (71% E max = 810 keV) and gamma rays (29% E max = 103 keV) of 153Sm (T½ = 46.3 h). Samarium-153 ethylene diamine tetramethylene phosphonate (153Sm-EDTMP) has been successfully applied as a radiopharmaceutical for palliation of metastatic bone pain at dose of 37 MBq/kg (1mCi/kg) intravenously. Blood samples from four healthy donors and three patients with no previous radiotherapy were exposed to 370, 555 (equivalent to the activity administrated in vivo) and 1110 kBq/mL during one hour in vitro. Then the lymphocytes were cultured for cytokinesis block micronucleus assay that has received increased attention for biological monitoring of radiation exposure. The MN induction in binucleated cells (BNC) at 370 and 555 kBq/mL was not significantly increased and showed no difference between the groups. This result may be explained as a consequence of the sensibility of this technique. The radiation damage to peripheral blood lymphocytes (PBL) exposed to 1110 kBq/mL may be considered to be equivalent to that observed after an external irradiation with 60Co at doses of 0.38 Gy in healthy donors (MN/BNC = 0.053 ± 0.041) and 0.51 Gy in patients (MN/BNC = 0.069 ± 0.040). This study showed that the use of 153 Sm-EDTMP induced no significant increase in the micronucleation of PBL at radioactive concentration lower than 555 kBq/mL (37MBq/kg) and also that the radiosensitivity of the patients was higher at 1110 kBq/mL than that of the healthy donors.
dc.format.extent1326-1329pt_BR
dc.identifier.citationSUZUKI, M.F.; SILVA, M.A.; GUIMARAES, M.I.C.C.; OKAZAKI, K. Induction of micronuclei by 153Sm-EDTMP in peripheral blood lymphocytes in vitro. <b>Journal of Nuclear Science and Technology</b>, p. 1326-1329, 2002. Supplement 2. DOI: <a href="https://dx.doi.org/10.1080/00223131.2002.10875349">10.1080/00223131.2002.10875349</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/6053.
dc.identifier.doi10.1080/00223131.2002.10875349
dc.identifier.issn0022-3131pt_BR
dc.identifier.suplementoSupplement 2pt_BR
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/6053pt_BR
dc.relation.ispartofJournal of Nuclear Science and Technologypt_BR
dc.rightsclosedAccessen
dc.subjectbiological radiation effectspt_BR
dc.subjectradiopharmaceuticalspt_BR
dc.subjectsamarium 153pt_BR
dc.subjectbeta particlespt_BR
dc.subjectgamma radiationpt_BR
dc.subjectlymphocytespt_BR
dc.subjectin vitropt_BR
dc.subjectradioinductionpt_BR
dc.subjectcell nucleipt_BR
dc.subjectskeletonpt_BR
dc.subjectmetastasespt_BR
dc.titleInduction of micronuclei by 153Sm-EDTMP in peripheral blood lymphocytes in vitropt_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorKAYO OKAZAKI
ipen.autorMIRIAM FUSSAE SUZUKI
ipen.autorMARCIA AUGUSTA DA SILVA
ipen.codigoautor1220
ipen.codigoautor557
ipen.codigoautor2589
ipen.contributor.ipenauthorKAYO OKAZAKI
ipen.contributor.ipenauthorMIRIAM FUSSAE SUZUKI
ipen.contributor.ipenauthorMARCIA AUGUSTA DA SILVA
ipen.date.recebimento03-03pt_BR
ipen.identifier.fi0.572pt_BR
ipen.identifier.ipendoc08666pt_BR
ipen.range.fi0.001 - 1.499
ipen.type.genreArtigo
relation.isAuthorOfPublication131eab71-499a-48c8-8f16-46ffafd0608f
relation.isAuthorOfPublicationda7833cb-421a-4163-9e42-8e06173b3242
relation.isAuthorOfPublicationae3998e8-9d0e-4bf0-b40f-92a4234f7463
relation.isAuthorOfPublication.latestForDiscoveryda7833cb-421a-4163-9e42-8e06173b3242
sigepi.autor.atividadeSUZUKI, M.F.:557:28:Spt_BR
sigepi.autor.atividadeSILVA, M.A.:2589:-1:Npt_BR
sigepi.autor.atividadeOKAZAKI, K.:1220:28:Npt_BR
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