Synthesis and characterization of hydrogels loaded neomycin for infection topic treatment and veterinary use
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Duclerc Fernandes Parra
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Resumo
Hydrogels are natural or synthetic polymer systems that have been vastly applied in
the pharmaceutical industry due to their high soft tissue biocompatibility. These
hydrogels have been used in dressings as a controlled drug release system. In this
study, hydrogels were prepared using poly (N-vinyl-2-pyrrolidone) (PVP), poly
(ethylene glycol) (PEG), agar and neomycin followed by gamma irradiation to promote
crosslinking and sterilization. The influence of the irradiation process at 25 kGy dose
was investigated. The gel fraction and maximum swelling were estimated using
physicochemical methods and found about 95% gel fraction and 1100% swelling after
8 hours of immersion. Neomycin released from the hydrogel was measured by the
Liquid Chromatography-Mass Spectrometry method and the drug concentration
remained constant for 48 hours. Hydrogel / neomycin exhibited antibacterial effect
against bacteria and biofilm of Pseudomonas aeruginosa and Staphylococcus aureus.
The hydrogel was used in the treatment of pododermatitis in penguins healing process
without signs of contamination. With these results, it can be inferred that the hydrogel /
neomycin is a suitable candidate for wound dressings.
Como referenciar
ZAFALON, ANGELICA T. Synthesis and characterization of hydrogels loaded neomycin for infection topic treatment and veterinary use. Orientador: Duclerc Fernandes Parra. 2018. 95 f. Tese (Doutorado em Tecnologia Nuclear) - Instituto de Pesquisas Energéticas e Nucleares - IPEN-CNEN/SP, São Paulo. DOI: 10.11606/T.85.2020.tde-08112018-113736. Disponível em: http://repositorio.ipen.br/handle/123456789/29836. Acesso em: 20 Mar 2026.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.