Using lanthanide chelates and uranyl compounds for diagnostic by fluoroimmunoassays
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2009
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INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE; MEETING ON NUCLEAR APPLICATIONS, 9th; MEETING ON REACTOR PHYSICS AND THERMAL HYDRAULICS, 16th; MEETING ON NUCLEAR INDUSTRY, 1st
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The importance of the luminescence of lanthanide ions and UO2
2+ is related to its peculiar characteristics, e.g.
long lifetime and line-like emission bands in the visible, which make these ions unique among the species that
are known to luminescence. Recent developments in the field of supramolecular chemistry have allowed the
design of ligands capable of encapsulating lanthanide ions, thus forming kinetically inert complexes. By
introduction of chromophoric groups in these ligands, an intense luminescence of the ion can be obtained via
the "antenna effect", defined as a light conversion process involving distinct absorbing (ligand) and emitting
(metal ion) components. In such a process, the quantities that contribute to the luminescence intensity are (i) the
efficiency of the absorption, (ii) the efficiency of the ligand-metal energy transfer, and (iii) the efficiency of the
metal luminescence. Encapsulation of lanthanide ions with suitable ligands may therefore give rise to
"molecular devices" capable to emit strong, long-lived luminescence. Besides the intrinsic interest in their
excited state properties, compounds of lanthanide ions, in particular of the Eu3+ and Tb3+ ions, and now UO2
2+
are important for their potential use as luminescent labels for biological species in fluoroimmunoassays (FIAs).
This is most interesting because fluorimetric labeling represents an alternative method to the use of radioactive
labels, which has long been the most common way of quantifying immunoreactions. In this article we report
information about luminescent materials, which gave a good signal to quantify biological molecules by TR-FIA,
DELFIA , DSLFIA, RIA and FRET.
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SANTOS, ELEN G.; TOMIYAMA, CLAUDIA S.; KODAIRA, CLAUDIA A.; LOURENCO, ANA V.S.; FELINTO, MARIA C.F.C.; BRITO, HERMI F.; BRITO, MARIA E.F. Using lanthanide chelates and uranyl compounds for diagnostic by fluoroimmunoassays. In: INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE; MEETING ON NUCLEAR APPLICATIONS, 9th; MEETING ON REACTOR PHYSICS AND THERMAL HYDRAULICS, 16th; MEETING ON NUCLEAR INDUSTRY, 1st, September 27 - October 2, 2009, Rio de Janeiro, RJ. Proceedings... Disponível em: http://repositorio.ipen.br/handle/123456789/16547. Acesso em: 13 Feb 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.