Development of somatostatin based radiopharmaceuticals for receptor mediated radionuclide therapy

Página do item simplificado
dc.contributor.authorARAUJO, E.B.pt_BR
dc.contributor.authorCALDEIRA FILHO, J.S.pt_BR
dc.contributor.authorNAGAMATI, L.T.pt_BR
dc.contributor.authorMURAMOTO, E.pt_BR
dc.contributor.authorCOLTURATO, M.T.pt_BR
dc.contributor.authorCOUTO, R.pt_BR
dc.contributor.authorOKASAKI, K.pt_BR
dc.contributor.authorSUZUKI, M.F.pt_BR
dc.contributor.authorGUIMARAES, M.I.C.C.pt_BR
dc.coverageInternacionalpt_BR
dc.date.accessioned2014-12-17T12:25:44Zpt_BR
dc.date.accessioned2014-12-17T12:54:59Z
dc.date.available2014-12-17T12:25:44Zpt_BR
dc.date.available2014-12-17T12:54:59Z
dc.date.issued2007pt_BR
dc.description.abstractThe paper describes the methodology used for and the results of labelling [Tyr3 ]octreotate (TATE) with radioiodine (131I) and [DOTA,Tyr3 ]octreotate (DOTATATE) with 131I and lutetium (177Lu). The quality control and purification procedures are also described. Biodistribution studies were performed in normal Swiss mice and in nude mice bearing AR42J tumours. In vitro studies were used to evaluate the affinity of the radiopharmaceuticals for somatostatin receptors in rat brain cortex and tumour cells. Saturation binding and the internalization of the labelled peptides were determined. The frequency of micronuclei in peripheral blood lymphocytes exposed to different radioactive concentrations of [131I]DOTATATE and [ 177Lu]DOTATATE was evaluated by micronucleus assay.
dc.format.extent27-52pt_BR
dc.identifier.citationARAUJO, E.B.; CALDEIRA FILHO, J.S.; NAGAMATI, L.T.; MURAMOTO, E.; COLTURATO, M.T.; COUTO, R.; OKASAKI, K.; SUZUKI, M.F.; GUIMARAES, M.I.C.C. Development of somatostatin based radiopharmaceuticals for receptor mediated radionuclide therapy. <b>Comparative Evaluation of Therapeutic Radiopharmaceuticals</b>. p. 27-52. Disponível em: http://repositorio.ipen.br/handle/123456789/23066.
dc.identifier.orcidhttps://orcid.org/0000-0003-0456-5589
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/23066pt_BR
dc.publisherVienna: IAEA, 2007pt_BR
dc.rightsopenAccesspt_BR
dc.subjectaffinitypt_BR
dc.subjectbrachytherapypt_BR
dc.subjectbrainpt_BR
dc.subjectin vitropt_BR
dc.subjectiodine 131pt_BR
dc.subjectlabellingpt_BR
dc.subjectlutetium 177pt_BR
dc.subjectlymphocytespt_BR
dc.subjectmicept_BR
dc.subjectpeptidespt_BR
dc.subjectpurificationpt_BR
dc.subjectquality controlpt_BR
dc.subjectradiation source implantspt_BR
dc.subjectradiopharmaceuticalspt_BR
dc.subjectratspt_BR
dc.subjectreceptorspt_BR
dc.subjectsomatostatinpt_BR
dc.titleDevelopment of somatostatin based radiopharmaceuticals for receptor mediated radionuclide therapypt_BR
dc.title.livroComparative Evaluation of Therapeutic Radiopharmaceuticalspt_BR
dc.typeCapítulo de livropt_BR
dspace.entity.typePublication
ipen.autorEMIKO MURAMOTO
ipen.autorMIRIAM FUSSAE SUZUKI
ipen.autorKAYO OKAZAKI
ipen.autorMARIA TEREZA COLTURATO
ipen.autorLUCIO TAKESHI MAGAMATI
ipen.autorJOSE DE SOUZA CALDEIRA FILHO
ipen.autorELAINE BORTOLETI DE ARAUJO
ipen.autorRENATA MARTINUSSI COUTO
ipen.codigoautor363
ipen.codigoautor557
ipen.codigoautor1220
ipen.codigoautor434
ipen.codigoautor3357
ipen.codigoautor1155
ipen.codigoautor664
ipen.codigoautor3441
ipen.contributor.ipenauthorEMIKO MURAMOTO
ipen.contributor.ipenauthorMIRIAM FUSSAE SUZUKI
ipen.contributor.ipenauthorKAYO OKAZAKI
ipen.contributor.ipenauthorMARIA TEREZA COLTURATO
ipen.contributor.ipenauthorLUCIO TAKESHI MAGAMATI
ipen.contributor.ipenauthorJOSE DE SOUZA CALDEIRA FILHO
ipen.contributor.ipenauthorELAINE BORTOLETI DE ARAUJO
ipen.contributor.ipenauthorRENATA MARTINUSSI COUTO
ipen.date.recebimento09-04pt_BR
ipen.identifier.ipendoc13639pt_BR
ipen.notas.conteudoTechnical Reports Series, n. 458, capitulo 3pt_BR
ipen.type.genreCapítulo
relation.isAuthorOfPublication6a06aa4c-97d4-4f06-b1c5-c23f131b7d14
relation.isAuthorOfPublicationda7833cb-421a-4163-9e42-8e06173b3242
relation.isAuthorOfPublication131eab71-499a-48c8-8f16-46ffafd0608f
relation.isAuthorOfPublicationf768e2ef-6a5d-416a-8fcf-851dfd1858d7
relation.isAuthorOfPublication3b7522ce-6b50-4cfe-8dbd-76201607efd7
relation.isAuthorOfPublication1bf4454d-fc89-4612-94d2-7ba85cbb9b50
relation.isAuthorOfPublicationca74886d-6974-47a8-9308-c4cc39bb6e35
relation.isAuthorOfPublication638cbe73-b71d-446d-83f7-3709eb6f483c
relation.isAuthorOfPublication.latestForDiscoveryca74886d-6974-47a8-9308-c4cc39bb6e35
sigepi.autor.atividadeARAUJO, E.B.:664:12:Spt_BR
sigepi.autor.atividadeCALDEIRA FILHO, J.S.:1155:12:Npt_BR
sigepi.autor.atividadeNAGAMATI, L.T.:3357:-1:Npt_BR
sigepi.autor.atividadeMURAMOTO, E.:363:12:Npt_BR
sigepi.autor.atividadeCOLTURATO, M.T.:434:12:Npt_BR
sigepi.autor.atividadeCOUTO, R.:3441:-1:Npt_BR
sigepi.autor.atividadeOKASAKI, K.:1220:18:Npt_BR
sigepi.autor.atividadeSUZUKI, M.F.:557:18:Npt_BR
Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
13639.pdf
Tamanho:
9.72 MB
Formato:
Adobe Portable Document Format
Baixar
Coleções
Capítulos