Labeling procedures for the preparation of sup(188)Re-DMSA(V)
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2009
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INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE; MEETING ON NUCLEAR APPLICATIONS, 9th; MEETING ON REACTOR PHYSICS AND THERMAL HYDRAULICS, 16th; MEETING ON NUCLEAR INDUSTRY, 1st
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188Re has received a lot of attention in the past decade, due to its favorable nuclear characteristics [t1/2 16.9 h, Eβ
max 2.12 MeV and Eγ
155 keV (15%) suitable for imaging], including the fact that it is carrier-free and can be
obtained cost-effectively through the generator 188W-188Re. Besides the therapeutic usefulness of 188Re, the
emission of the 155 keV gamma photon is an added advantage since the biodistribution of 188Re-labeled agents
can be evaluated in vivo with a gamma camera. Biodistribution studies of 188Re-DMSA(V) have shown that its
general pharmacokinetic properties are similar to that of 99mTc-DMSA(V), so this agent could be used for
targeted radiotherapy of the same tumors, i.e., medullary thyroid carcinoma, bone metastases, soft tissue, head
and neck tumors. The aim of this work is to evaluate two labeling procedures for the preparation of 188ReDMSA(V). 188Re-DMSA(V) was prepared by two methods. The first method was prepared using a commercial
kit of DMSA(III) for labeling with 99mTc, at high temperature (100oC). The second method was prepared in a
vial containing 2.5 mg of DMSA, 1.00 mg of SnCl2.2H2O and 30 mg of sodium oxalate, in a total volume of 1.1
mL. The pH was adjusted to 5 with 37% HCl. After labeling the solution was stirred and incubated for 15 min at
room temperature. The radiochemical purity was determined using TLC-SG developed with two different
solvent systems. Preliminary results for both methods of labeling 188Re-DMSA(V) showed that the labeling
yield was >90%.
Como referenciar
BRAMBILLA, TANIA P.; OSSO JUNIOR, JOAO A. Labeling procedures for the preparation of sup(188)Re-DMSA(V). In: INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE; MEETING ON NUCLEAR APPLICATIONS, 9th; MEETING ON REACTOR PHYSICS AND THERMAL HYDRAULICS, 16th; MEETING ON NUCLEAR INDUSTRY, 1st, September 27 - October 2, 2009, Rio de Janeiro, RJ. Proceedings... Disponível em: http://repositorio.ipen.br/handle/123456789/16543. Acesso em: 20 Mar 2026.
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