Effect of ozone therapy on wound healing in the buccal mucosa of rats
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Archives of Oral Biology
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Objective: The objective of this study was to evaluate the effects of ozone therapy on wound healing formed
experimentally in the oral cavity of rats.
Design: Two surgical wounds were generated on the cheeks of 24 Wistar rats, bilaterally. Half of the animals were
submitted to ozone therapy on both wounds (experimental group) and the other half received no treatment
(control group). In the experimental group, wounds were exposed to ozone gas 1, 2 or 3 (60 μg/mL) times.
Evaluation of wound healing of the buccal mucosa was followed for 1, 3 and 7 days. The distribution of neutrophils,
fibroplasia and angiogenesis were analyzed. Samples were classified in a healing numerical scale according
to the inflammatory intensity. Data were submitted to Mann-Whitney and Kruskal-Wallis tests (α =
0.05).
Results: On day 1, wounds were similar in both groups, lesions were open and bloody with slightly minor
bleeding in the ozone therapy group. On day 3, the group with ozone therapy was almost all refurbished and with
higher angiogenesis, while the control group still had more bloody points and lower blood vessels. On day 7, both
wounds were remodeled, with higher fibroplasia in the group that received ozone therapy.
Conclusion: It can be concluded that ozone therapy was effective in improving angiogenesis and fibroblasts count
in the buccal mucosa of rats.
Como referenciar
PCHEPIORKA, ROBSON; MOREIRA, MARIA S.; LASCANE, NELISE A. da S.; CATALANI, LUIZ H.; ALLEGRINI JUNIOR, SERGIO; LIMA, NELSON B. de; GONÇALVES, FLAVIA. Effect of ozone therapy on wound healing in the buccal mucosa of rats. Archives of Oral Biology, v. 119, p. 1-7, 2020. DOI: 10.1016/j.archoralbio.2020.104889. Disponível em: http://200.136.52.105/handle/123456789/31592. Acesso em: 31 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.