Anti-calcifying treatment of glutaraldehyde fixed bovine pericardium
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Revista Brasileira de Cirurgia Cardiovascular
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Objective: To evaluate a possible synergic effect of the most
promising anti-calcifying agents investigated in the literature
by sequential treatment.
Method: Glutaraldehyde-fixed bovine pericardium was
treated by: heating to 50º C, 80% ether, 0.125% chitosan,
heparin, NaBH4
and 4% formaldehyde. Samples were
evaluated by optic microscopy, shrinking and mechanical tests
and implanted subcutaneously in rats. Four months later the
samples were explanted and Ca2+ levels measured by atomic
absorption spectroscopy.
Results: The Ca2+ levels were (in µg/mg): control: 194.45;
heating to 50ºC: 6.87; ether: 3.69; chitosan: 68.89; heparin:
6.81; formaldehyde: 107.34; sequential treatment: 0.17. The
mechanical characteristics changed according to treatments
employed.
Conclusion: Sequential treatment was effective to inhibit
calcification and the tissue showed an adequate mechanical
structure for the manufacture of bioprosthesis.
Como referenciar
BAUCIA, JOSE A.; LEAL NETO, RICARDO M.; ROGERO, JOSE R.; NASCIMENTO, NANCI do. Anti-calcifying treatment of glutaraldehyde fixed bovine pericardium: comparisons and evaluation of possible synergic effects. Revista Brasileira de Cirurgia Cardiovascular, v. 21, n. 2, p. 180-187, 2006. Disponível em: http://repositorio.ipen.br/handle/123456789/5413. Acesso em: 20 Mar 2026.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.