Synthesis, in vitro testing, and biodistribution of surfactant-free radioactive nanoparticles for cancer treatment

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dc.contributor.authorSOUZA, CARLA D. dept_BR
dc.contributor.authorBARBEZAN, ANGELICA B.pt_BR
dc.contributor.authorROSERO, WILMMER A.A.pt_BR
dc.contributor.authorSANTOS, SOFIA N. dospt_BR
dc.contributor.authorCARVALHO, DIEGO V. de S.pt_BR
dc.contributor.authorZEITUNI, CARLOS A.pt_BR
dc.contributor.authorBERNARDES, EMERSON S.pt_BR
dc.contributor.authorVIEIRA, DANIEL P.pt_BR
dc.contributor.authorSPENCER, PATRICK J.pt_BR
dc.contributor.authorRIBEIRO, MARTHA S.pt_BR
dc.contributor.authorROSTELATO, MARIA E.C.M.pt_BR
dc.coverageInternacionalpt_BR
dc.date.accessioned2022-05-05T11:09:50Z
dc.date.available2022-05-05T11:09:50Z
dc.date.issued2022pt_BR
dc.description.abstractNew forms of cancer treatment, which are effective, have simple manufacturing processes, and easily transportable, are of the utmost necessity. In this work, a methodology for the synthesis of radioactive Gold-198 nanoparticles without the use of surfactants was described. The nuclear activated Gold-198 foils were transformed into H198AuCl4 by dissolution using aqua regia, following a set of steps in a specially designed leak-tight setup. Gold-198 nanoparticles were synthesized using a citrate reduction stabilized with PEG. In addition, TEM results for the non-radioactive product presented an average size of 11.0 nm. The DLS and results for the radioactive 198AuNPs presented an average size of 8.7 nm. Moreover, the DLS results for the PEG-198AuNPs presented a 32.6 nm average size. Cell line tests showed no cytotoxic effect in any period and the concentrations were evaluated. Furthermore, in vivo testing showed a high biological uptake in the tumor and a cancer growth arrest.pt_BR
dc.description.sponsorshipInstituto de Pesquisas Energéticas e Nucleares (IPEN)pt_BR
dc.description.sponsorshipInternational Atomic Energy Agency (IAEA)pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipIDIPEN: 2018.05.IPEN.09pt_BR
dc.description.sponsorshipIDIAEA: BRA6026pt_BR
dc.description.sponsorshipIDFAPESP: 17/50332-0; 18/18526-2pt_BR
dc.description.sponsorshipIDCNPq: 465763/2014-6pt_BR
dc.format.extent1-13pt_BR
dc.identifier.citationSOUZA, CARLA D. de; BARBEZAN, ANGELICA B.; ROSERO, WILMMER A.A.; SANTOS, SOFIA N. dos; CARVALHO, DIEGO V. de S.; ZEITUNI, CARLOS A.; BERNARDES, EMERSON S.; VIEIRA, DANIEL P.; SPENCER, PATRICK J.; RIBEIRO, MARTHA S.; ROSTELATO, MARIA E.C.M. Synthesis, in vitro testing, and biodistribution of surfactant-free radioactive nanoparticles for cancer treatment. <b>Nanomaterials</b>, v. 12, n. 2, p. 1-13, 2022. DOI: <a href="https://dx.doi.org/10.3390/nano12020187">10.3390/nano12020187</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/33035.
dc.identifier.doi10.3390/nano12020187pt_BR
dc.identifier.fasciculo2pt_BR
dc.identifier.issn2079-4991pt_BR
dc.identifier.orcid0000-0003-2943-6097pt_BR
dc.identifier.orcid0000-0002-4203-1134pt_BR
dc.identifier.orcid0000-0001-8949-7735pt_BR
dc.identifier.orcid0000-0002-0007-534Xpt_BR
dc.identifier.orcid0000-0002-0029-7313pt_BR
dc.identifier.orcid0000-0002-7303-6720pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0029-7313
dc.identifier.orcidhttps://orcid.org/0000-0003-2943-6097
dc.identifier.orcidhttps://orcid.org/0000-0002-4203-1134
dc.identifier.orcidhttps://orcid.org/0000-0001-8949-7735
dc.identifier.orcidhttps://orcid.org/0000-0002-0007-534X
dc.identifier.orcidhttps://orcid.org/0000-0002-7303-6720
dc.identifier.orcidhttp://orcid.org/0000-0003-1335-8864
dc.identifier.percentilfi66.5pt_BR
dc.identifier.percentilfiCiteScore79.5pt_BR
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/33035
dc.identifier.vol12pt_BR
dc.relation.ispartofNanomaterialspt_BR
dc.rightsopenAccesspt_BR
dc.subjectradioactivity
dc.subjectnanoparticles
dc.subjectbrachytherapy
dc.subjectneoplasms
dc.subjecttesting
dc.subjectin vivo
dc.subjectin vitro
dc.subjectgold 198
dc.subjectdistribution
dc.titleSynthesis, in vitro testing, and biodistribution of surfactant-free radioactive nanoparticles for cancer treatmentpt_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorANGELICA BUENO BARBEZAN
ipen.autorSOFIA NASCIMENTO DOS SANTOS
ipen.autorEMERSON SOARES BERNARDES
ipen.autorMARIA ELISA CHUERY MARTINS ROSTELATO
ipen.autorMARTHA SIMOES RIBEIRO
ipen.autorPATRICK JACK SPENCER
ipen.autorDANIEL PEREZ VIEIRA
ipen.autorCARLOS ALBERTO ZEITUNI
ipen.autorDIEGO VERGAÇAS DE SOUSA CARVALHO
ipen.autorWILMMER ALEXANDER ARCOS ROSERO
ipen.autorCARLA DARUICH DE SOUZA
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ipen.contributor.ipenauthorANGELICA BUENO BARBEZAN
ipen.contributor.ipenauthorSOFIA NASCIMENTO DOS SANTOS
ipen.contributor.ipenauthorEMERSON SOARES BERNARDES
ipen.contributor.ipenauthorMARIA ELISA CHUERY MARTINS ROSTELATO
ipen.contributor.ipenauthorMARTHA SIMOES RIBEIRO
ipen.contributor.ipenauthorPATRICK JACK SPENCER
ipen.contributor.ipenauthorDANIEL PEREZ VIEIRA
ipen.contributor.ipenauthorCARLOS ALBERTO ZEITUNI
ipen.contributor.ipenauthorDIEGO VERGAÇAS DE SOUSA CARVALHO
ipen.contributor.ipenauthorWILMMER ALEXANDER ARCOS ROSERO
ipen.contributor.ipenauthorCARLA DARUICH DE SOUZA
ipen.date.recebimento22-05
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sigepi.autor.atividadeROSTELATO, MARIA E.C.M.:7:230:Npt_BR
sigepi.autor.atividadeRIBEIRO, MARTHA S.:574:920:Npt_BR
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sigepi.autor.atividadeBARBEZAN, ANGELICA B.:6417:230:Npt_BR
sigepi.autor.atividadeSOUZA, CARLA D. de:7717:230:Spt_BR
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