O-glycan sialylation alters galectin-3 subcellular localization and decreases chemotherapy sensitivity in gastric cancer
Carregando...
Data
Data de publicação
Autores IPEN
Orientador
Título da Revista
ISSN da Revista
Título do Volume
É parte de
É parte de
É parte de
Oncotarget
ODS
Exportar
Resumo
ST6GalNAc-I, the sialyltransferase responsible for sialyl-Tn (sTn) synthesis, has
been previously reported to be positively associated with cancer aggressiveness. Here
we describe a novel sTn-dependent mechanism for chemotherapeutic resistance. We
show that sTn protects cancer cells against chemotherapeutic-induced cell death
by decreasing the interaction of cell surface glycan receptors with galectin-3 and
increasing its intracellular accumulation. Moreover, exogenously added galectin-3
potentiated the chemotherapeutics-induced cytotoxicity in sTn non-expressing cells,
while sTn overexpressing cells were protected. We also found that the expression
of sTn was associated with a reduction in galectin-3-binding sites in human gastric
samples tumors. ST6GalNAc-I knockdown restored galectin-3-binding sites on the cell
surface and chemotherapeutics sensibility. Our results clearly demonstrate that an
interruption of O-glycans extension caused by ST6GalNAc-I enzymatic activity leads
to tumor cells resistance to chemotherapeutic drugs, highlighting the need for the
development of novel strategies to target galectin-3 and/or ST6GalNAc-I.
Como referenciar
SANTOS, SOFIA N.; JUNQUEIRA, MARA S.; FRANCISCO, GUILHERME; VILANOVA, MANUEL; MAGALHAES, ANA; BARUFFI, MARCELO D.; CHAMMAS, ROGER; HARRIS, ADRIAN L.; REIS, CELSO A.; BERNARDES, EMERSON S. O-glycan sialylation alters galectin-3 subcellular localization and decreases chemotherapy sensitivity in gastric cancer. Oncotarget, v. 7, n. 50, p. 83570-83587, 2016. DOI: 10.18632/oncotarget.13192. Disponível em: http://repositorio.ipen.br/handle/123456789/27210. Acesso em: 20 Mar 2026.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.